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Titolo:
Benidipine inhibits expression of ET-1 and TGF-beta 1 in Dahl salt-sensitive hypertensive rats
Autore:
Kobayashi, N; Nakano, S; Mori, Y; Kobayashi, T; Tsubokou, Y; Matsuoka, H;
Indirizzi:
Dokkyo Univ, Sch Med, Dept Hypertens & Cardiorenal Med, Mibu, Tochigi 3210293, Japan Dokkyo Univ Mibu Tochigi Japan 3210293 Med, Mibu, Tochigi 3210293, Japan
Titolo Testata:
Hypertension research
fascicolo: 3, volume: 24, anno: 2001,
pagine: 241 - 250
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR HYPERTROPHY; RECEPTOR MESSENGER-RNA; NITRIC-OXIDE SYNTHASE; GENE-EXPRESSION; HUMAN-PLATELETS; BLOOD-PRESSURE; ETA-RECEPTOR; CDNA CLONING; ENDOTHELIN-1; IMIDAPRIL;
Keywords:
calcium antagonist; endothelin; gene expression; growth factor; remodeling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Kobayashi, N Dokkyo Univ, Sch Med, Dept Hypertens & Cardiorenal Med, Mibu,Tochigi 3210293, Japan Dokkyo Univ Mibu Tochigi Japan 3210293 ochigi 3210293, Japan
Citazione:
N. Kobayashi et al., "Benidipine inhibits expression of ET-1 and TGF-beta 1 in Dahl salt-sensitive hypertensive rats", HYPERTENS R, 24(3), 2001, pp. 241-250

Abstract

Endothelin and growth factors such as transforming growth factor(TGF)-beta1 are important regulators of the cardiovascular system. Although increasedproduction of endotfielin-1 (ET-1) and TGF-beta1 have been reported in left ventricular hypertrophy, the detailed roles of these substances in hypertrophy remain to be determined. To elucidate the cardioprotective effects ofcalcium antagonists in left ventricular hypertrophy, we evaluated the effects of long-term treatment with benidipine, a long-acting calcium antagonist, on preproET-1, ETA receptor (ETAR) and TGF-beta1 expression in the left ventricle and evaluated the relations between these effects and myocardial remodeling in Dahl salt-sensitive hypertensive (DS) rats fed a high-salt diet. After 5 weeks of feeding an 8% NaCl diet to 6-week-old DS rats (i.e., at 11 weeks of age), a distinct stage of concentric left Ventricular hypertrophy (DSLVH) was noted. Benidipine (DSLVH-B group, n=8; 1 mg/kg/day, subdepressor dose) or vehicle (DSLVH-V group, n=8) was administered to 6-week-oldDS rats for 5 weeks, or until the onset of DSLVH stage, and age-matched (11-week-old) Dahl salt-resistant rats fed the same diet served as a control group (DR-C, n=8). Blood pressure was similar between the DSLVH-B and DSLVH-V groups, but was significantly lower in DR-C rats. The preproET-1, ETAR and TGF-beta1 expressions in the left ventricle were significantly higher inDSLVH-V than in DR-C rats, end significantly lower in DSLVH-B than in DSLVH-V, Benidipine administration resulted in significant improvements in the wall-to-lumen ratio and perivascular fibrosis in the coronary arterioles, and in myocardial fibrosis. We therefore concluded that myocardial remodeling and left ventricular hypertrophy in DS hypertensive rats fed a high-salt diet were significantly ameliorated by a subdepressor dose of benidipine, and that this amelioration was partly due to decreases in the expression of ET-1 and TGF-beta1 in the left ventricle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:37:13