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Titolo:
Diurnal variation of hemodynamic indices in non-dipper hypertensive patients
Autore:
Takakuwa, H; Ise, T; Kato, T; Izumiya, Y; Shimizu, K; Yokoyama, H; Kobayashi, K;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Internal Med 1, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208641 wa, Ishikawa 9208641, Japan Kanazawa Univ, Div Blood Purificat, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208641 wa, Ishikawa 9208641, Japan
Titolo Testata:
Hypertension research
fascicolo: 3, volume: 24, anno: 2001,
pagine: 195 - 201
Fonte:
ISI
Lingua:
ENG
Soggetto:
SILENT CEREBROVASCULAR DAMAGE; BLOOD-PRESSURE CHANGES; CARDIAC-OUTPUT; SYSTEMIC HEMODYNAMICS; CIRCADIAN-RHYTHM; ELDERLY PATIENTS; PULSE CONTOUR; BAROREFLEX; HEMODIALYSIS; SENSITIVITY;
Keywords:
ambulatory blood pressure monitoring; pulse contour analysis; baroreflex sensitivity; non-dippers; hemodynamics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Takakuwa, H Kanazawa Univ, Sch Med, Dept Internal Med 1, 13-1 Takaramachi,Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ 13-1 Takaramachi Kanazawa Ishikawa Japan 9208641
Citazione:
H. Takakuwa et al., "Diurnal variation of hemodynamic indices in non-dipper hypertensive patients", HYPERTENS R, 24(3), 2001, pp. 195-201

Abstract

The purpose of this study was to elucidate the underlying mechanisms of blunted nocturnal blood pressure reduction in non-dipper hypertensive patients, We studied the diurnal variations in systemic hemodynamic indices and baroreflex sensitivity. In 45 subjects with essential hypertension (24 men; mean age, 49 +/-1 years), intra-arterial pressure was monitored telemetrically. Non-dippers were defined as those with a nocturnal reduction of systolic blood pressure of less than 10% of daytime systolic blood pressure, Stroke volume was determined using Wesseling's pulse contour method, calibrated with indocyanine green dilution. Baroreflex sensitivity was calculated as Delta pulse interval/Delta systolic blood pressure on spontaneous variations. The mean values of the hemodynamic parameters were calculated every 30 min. Twenty-six subjects were classified as non-dippers, Daytime blood pressure was not significantly different between dippers (149 +/-4/87 +/-3 mmHg) and non-dippers (147 +/-3/82 +/-2 mmHg), while the nighttime blood pressurewas significantly reduced in dippers (131 +/-3/77 +/-2 mmHg) but not in non-dippers (145 +/-3/80 +/-2 mmHg), Nocturnal decreases in both cardiac index and stroke index were smaller in non-dippers (-12.0 +/-1.2% and 1.5 +/-1.0%) than in dippers (-17.5 +/-1.4% and -2.2 +/-1.1%), Baroreflex sensitivity significantly increased at nighttime both in dippers (6.5 +/-0.6 to 8.0 +/-0.7 ms/mmHg) and in non-dippers(5.1 +/-0.3 to 6.4 +/-0.4 ms/mmHg). Neither daytime nor nighttime baroreflex sensitivity was significantly different between the groups. We conclude that the hemodynamics of non-dipper essential hypertension are characterized by an inadequate nocturnal decrease in cardiac index and stroke index, suggestive of relative volume expansion or malsuppressed sympathetic activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 08:09:08