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Titolo:
Increased aneuploidy in spermatozoa from testicular tumour patients after chemotherapy with cisplatin, etoposide and bleomycin
Autore:
De Mas, P; Daudin, M; Vincent, MC; Bourrouillou, G; Calvas, P; Mieusset, R; Bujan, L;
Indirizzi:
Hop La Grave, Human Fertil Res Grp, F-31052 Toulouse, France Hop La GraveToulouse France F-31052 l Res Grp, F-31052 Toulouse, France Hop La Grave, CECOS Midi Pyrenees, Ctr Sterilite Masculine, Serv Uroandrol, F-31052 Toulouse, France Hop La Grave Toulouse France F-31052 Uroandrol, F-31052 Toulouse, France Hop Purpan, Serv Genet Med, Toulouse, France Hop Purpan Toulouse FranceHop Purpan, Serv Genet Med, Toulouse, France
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 6, volume: 16, anno: 2001,
pagine: 1204 - 1208
SICI:
0268-1161(200106)16:6<1204:IAISFT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-SITU HYBRIDIZATION; DNA TOPOISOMERASE-II; HUMAN SPERM NUCLEI; GERM-CELL TUMORS; CHROMOSOMAL-ABNORMALITIES; ADJUVANT CHEMOTHERAPY; INHIBITOR ETOPOSIDE; CANCER-PATIENTS; ABERRATIONS; MITOSIS;
Keywords:
chemotherapy; FISH; PEB side effects; sperm aneuploidy; testicular cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Bujan, L Hop La Grave, Human Fertil Res Grp, F-31052 Toulouse, France Hop La Grave Toulouse France F-31052 , F-31052 Toulouse, France
Citazione:
P. De Mas et al., "Increased aneuploidy in spermatozoa from testicular tumour patients after chemotherapy with cisplatin, etoposide and bleomycin", HUM REPR, 16(6), 2001, pp. 1204-1208

Abstract

Testicular cancer is the most common neoplasia occurring in the young malepopulation. The FEB (cisplatin, etoposide and bleomycin) adjuvant chemotherapy usually proposed after orchidectomy in non seminomatous tumours, and in metastatic seminomas, has improved the long-term survival of these patients, Following an azoospermic period, sperm cell recovery is generally observed after treatment delivery, but little is known about the genetic consequences on these new spermatozoa, To estimate the chromosomal consequences ofthis chemotherapy on sperm cells during the period of recovery of spermatogenesis, sperm cell aneuploidy was studied in testicular cancer patients, at 6-18 months after FEB adjuvant chemotherapy delivery, using fluorescence in-situ hybridization (FISH) of chromosomes 7, 16, 18, X and Y with specific DNA probes. A significant increase in the frequency of diploidy and disomy for chromosomes 16, 18 and XY was observed in treated patients compared with a healthy control group. Spermatozoa aneuploidy occurring during the spermatogenesis recovery period might be a possible side effect of the FEB regimen, Thus, practitioners should be advised to provide counselling about the need for an appropriate duration of contraception. Moreover, genetic counselling should be offered in cases of pregnancy occurring soon after the end of chemotherapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 23:29:02