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Titolo:
Immunohistochemical analysis of diethylstilbestrol-induced renal tumors inadult male Syrian hamsters: evidence for relationship to peripheral nerve sheath tumors
Autore:
Toubeau, G; Nonclercq, D; Laurent, G; Brohee, R; Zanen, J; Heuson-Stiennon, JA; Van Cauwenberge, A; Alexandre, H; Falmagne, P;
Indirizzi:
Univ Mons Hainaut, Fac Med & Pharm, Lab Histol & Expt Cytol, B-7000 Mons, Belgium Univ Mons Hainaut Mons Belgium B-7000 & Expt Cytol, B-7000 Mons, Belgium Univ Mons Hainaut, Fac Med & Pharm, Lab Biol & Embryol, B-7000 Mons, Belgium Univ Mons Hainaut Mons Belgium B-7000 ol & Embryol, B-7000 Mons, Belgium Univ Mons Hainaut, Fac Sci, Dept Biol Chem, B-7000 Mons, Belgium Univ MonsHainaut Mons Belgium B-7000 pt Biol Chem, B-7000 Mons, Belgium
Titolo Testata:
HISTOCHEMISTRY AND CELL BIOLOGY
fascicolo: 5, volume: 115, anno: 2001,
pagine: 429 - 438
SICI:
0948-6143(200105)115:5<429:IAODRT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED KIDNEY TUMORS; PRIMITIVE NEUROECTODERMAL TUMOR; NEURON-SPECIFIC ENOLASE; GOLDEN-HAMSTER; GLIAL-CELLS; ORIGIN; LOCALIZATION; PROTEIN; CARCINOGENESIS; MARKERS;
Keywords:
confocal microscopy; estrogens; peripheral nerve sheath; Schwann cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Toubeau, G Univ Mons Hainaut, Fac Med & Pharm, Lab Histol & Expt Cytol, Ave Champ Mars 6,Pentagone 1B, B-7000 Mons, Belgium Univ Mons Hainaut Ave Champ Mars 6,Pentagone 1B Mons Belgium B-7000
Citazione:
G. Toubeau et al., "Immunohistochemical analysis of diethylstilbestrol-induced renal tumors inadult male Syrian hamsters: evidence for relationship to peripheral nerve sheath tumors", HISTOCHEM C, 115(5), 2001, pp. 429-438

Abstract

Estrogen-induced Syrian hamster kidney tumors (SHKT) are widely used as experimental models for the study of hormonal and renal carcinogenesis. In order to characterize the direction of differentiation of SHKT, kidney sections of diethylstilbestrol (DES)-treated hamsters (1-11 months) were analyzedby immunohistochemistry using a panel of lineage-specific markers. The first tumorous buds found in animals exposed to DES for 4-6 months exhibited prominent S100, Leu-7, and vimentin immunoreactivities. Immunopositivities for neuron-specific enolase, PGP 9.5, desmin, and glial fibrillary acidic protein were mostly detected in medium-sized and large tumors after prolongedexposure to DES (>6 months). All neoplasms, irrespective of the size and the duration of treatment, appeared negative for cytokeratin, neurofilaments, synaptophysin, and CD99 antibodies. Western blotting confirmed to a largeextent the immunohistochemical observations. The systematic analysis of serial kidney sections by confocal microscopy after double immunostaining forS100 and neurofilaments revealed that early neoplastic buds could stem from S100-positive cells associated with nerves bundles. Altogether, these observations suggest that DES-induced SHKT could be related to malignant peripheral nerve sheath tumor and originate from a yet unidentified precursor cell present in the sheath of peripheral nerves.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:07:21