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Titolo:
Auditory cortical neuron response differences under isoflurane versus pentobarbital anesthesia
Autore:
Cheung, SW; Nagarajan, SS; Bedenbaugh, PH; Schreiner, CE; Wang, XQ; Wong, A;
Indirizzi:
Univ Calif San Francisco, Coleman Mem Lab, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, WM Keck Ctr Integrat Neurosci, San Francisco, CA94143 USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco, CA94143 USA Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA Univ Utah Salt LakeCity UT USA 84112 oengn, Salt Lake City, UT 84112 USA Univ Florida, Inst Brain, Dept Neurosci, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 Neurosci, Gainesville, FL 32610 USA Univ Florida, Inst Brain, Dept Otolaryngol, Gainesville, FL 32610 USA UnivFlorida Gainesville FL USA 32610 laryngol, Gainesville, FL 32610 USA Johns Hopkins Sch Med, Dept Biomed Engn, Baltimore, MD 21205 USA Johns Hopkins Sch Med Baltimore MD USA 21205 ngn, Baltimore, MD 21205 USA Johns Hopkins Sch Med, Dept Neurosci, Baltimore, MD 21205 USA Johns Hopkins Sch Med Baltimore MD USA 21205 sci, Baltimore, MD 21205 USA Western Univ Hlth Sci, Coll Osteopath Med Pacific, Pomona, CA 91766 USA Western Univ Hlth Sci Pomona CA USA 91766 d Pacific, Pomona, CA 91766 USA
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 156, anno: 2001,
pagine: 115 - 127
SICI:
0378-5955(200106)156:1-2<115:ACNRDU>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINGLE-UNIT ACTIVITY; FUNCTIONAL TOPOGRAPHY; TONE INTENSITY; COMPLEX SOUNDS; VISUAL-CORTEX; TUNING CURVES; CAT; REPRESENTATION; POTENTIALS; RECORDINGS;
Keywords:
auditory cortex; isoflurane; pentobarbital; anesthesia; frequency tuning curve; cat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Cheung, SW Div Otol Neurol & Skull Base Surg, Box 0342 A730,400 Parnassus Ave, San Francisco, CA 94143 USA Div Otol Neurol & Skull Base Surg Box 0342A730,400 Parnassus Ave San Francisco CA USA 94143
Citazione:
S.W. Cheung et al., "Auditory cortical neuron response differences under isoflurane versus pentobarbital anesthesia", HEARING RES, 156(1-2), 2001, pp. 115-127

Abstract

Response properties of the middle layers of feline primary auditory cortexneurons to simple sounds were compared for isoflurane versus pentobarbitalanesthesia in a within subject study control design. Initial microelectrode recordings were made under isoflurane anesthesia. After a several hour washout period, recordings were repeated at spatially matched locations in the same animal under pentobarbital. The median spatial separation between matched recording locations was 50 microns. Excitatory frequency tuning curves (n = 71 pairs) to tone bursts and entrainment to click train sequences (n= 64 pairs) ranging from 2 to 38 Hz were measured. Characteristic frequency and BW10 and BW30 were not different under either anesthetic. The spontaneous rate was slightly decreased (P < 0.05) for isoflurane (median 4.2 spikes/s) compared to pentobarbital (median 5.8 spikes/s). Minimum median threshold and latency were elevated by 12 dB and 2 ms, respectively, under isoflurane. Entrainment to click sequences assumed a lowpass filter profile under both anesthetics, but was markedly impoverished under isoflurane. Responses to click sequences under isoflurane were phasic to the first click but had very poor following to subsequent elements. Compared to pentobarbital, isoflurane appears to have a profound impact on response sensitivity and temporal response properties of auditory cortical neurons. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 30/03/20 alle ore 19:41:34