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Titolo:
Temporary and permanent noise-induced changes in distortion product otoacoustic emissions in CBA/CaJ mice
Autore:
Vazquez, AE; Luebke, AE; Martin, GK; Lonsbury-Martin, BL;
Indirizzi:
Univ Miami, Dept Otolaryngol, Miami, FL 33101 USA Univ Miami Miami FL USA33101 iami, Dept Otolaryngol, Miami, FL 33101 USA Univ Miami, Sch Med, Neurosci Program, Miami, FL 33152 USA Univ Miami Miami FL USA 33152 Med, Neurosci Program, Miami, FL 33152 USA
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 156, anno: 2001,
pagine: 31 - 43
SICI:
0378-5955(200106)156:1-2<31:TAPNCI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED HEARING-LOSS; AGE-RELATED LOSS; ACOUSTIC INJURY; THRESHOLD SHIFT; MOUSE COCHLEA; EXPOSURE; EAR; PROTECTION; TRAUMA; EFFERENT;
Keywords:
noise damage; cochlea; distortion product otoacoustic emission; mouse; acetylcholinesterase; efferent innervation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Vazquez, AE Univ Miami, Dept Otolaryngol, M805,POB 016960, Miami, FL 33101USA Univ Miami M805,POB 016960 Miami FL USA 33101 mi, FL 33101 USA
Citazione:
A.E. Vazquez et al., "Temporary and permanent noise-induced changes in distortion product otoacoustic emissions in CBA/CaJ mice", HEARING RES, 156(1-2), 2001, pp. 31-43

Abstract

A number of studies have shown that the ear can be protected from sound over-exposure, either by activating the cochlear efferent system, or by sound'conditioning' in which the role of the efferent system is less certain. To study more definitively the molecular basis of deliberately induced cochlear protection from excessive sounds, it is advantageous to determine, for an inbred mouse strain, a range of noise exposure parameters that effectively alter cochlear function. As an initial step towards this goal, young CBA/CaJ mice were exposed to a 105-dB SPL octave-band noise (OBN), centered at10 kHz, for Various lengths of time consisting of 10 min, or 0.5, 1, 3, or6 h. Distortion product otoacoustic emissions (DPOAEs) at the 2f(1)-f(2) frequency, in response to equilevel primary tones of low to moderate levels,were used to quantify the damaging effects of these sound over-exposures on cochlear function. In addition, staining for acetylcholinesterase (AChE) activity to assess for noise-induced changes in the pattern of efferent-nerve innervation to the cochlea was also performed in a subset of mice that were exposed to the longest-lasting 6-h OBN. The 10-min OBN resulted in onlytemporary reductions in DPOAE levels, which recovered to pre-exposure Values within 5 days. Increasing the exposure to 0.5 h resulted in permanent DPOAE losses that, for low primary-tone levels: were still present at 31 dayspost-exposure. Additionally, the l-h and longer exposures caused permanentreductions in DPOAEs for all test levels, which were measurable at 31 daysfollowing exposure. Light-microscopic observations restricted to the 11-18-kHz frequency region of the organ of Corti, for a subset of mice exposed to the 6-h OBN, uncovered a significant loss of outer hair cells (OHCs). However: despite the OHC loss in this region, the AChE activity associated with the related pattern of efferent innervation remained largely intact. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 19:03:03