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Titolo:
PPADS, an ATP antagonist, attenuates the effects of a moderately intense sound on cochlear mechanics
Autore:
Bobbin, RP;
Indirizzi:
Louisiana State Univ, Med Ctr, Dept Otohinolaryngol & Biocommun, Kresge Hearing Res Lab, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 156, anno: 2001,
pagine: 10 - 16
SICI:
0378-5955(200106)156:1-2<10:PAAAAT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG COCHLEA; OUTER HAIR-CELLS; PHARMACOLOGICAL EVIDENCE; DISTORTION PRODUCTS; THRESHOLD SHIFT; ACOUSTIC INJURY; RECEPTOR; NOISE; SURAMIN; EXCITOTOXICITY;
Keywords:
pyridoxal-phosphate-6-azophenyl-2 ',4 '-disulphonic acid; distortion product; intense tone; noise; ototoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Bobbin, RP Louisiana State Univ, Med Ctr, Dept Otohinolaryngol & Biocommun, Kresge Hearing Res Lab, 533 Bolivar St,5th Floor, New Orleans, LA 70112 USA Louisiana State Univ 533 Bolivar St,5th Floor New Orleans LA USA 70112
Citazione:
R.P. Bobbin, "PPADS, an ATP antagonist, attenuates the effects of a moderately intense sound on cochlear mechanics", HEARING RES, 156(1-2), 2001, pp. 10-16

Abstract

Increasing attention is being given to the role of neurotransmitters and other signaling substances in the damage induced by intense sound to the cochlea. Adenosine triphosphate (ATP) is one example of a putative neurotransmitter that may alter cochlear mechanics during sound exposure. The purpose of the present study was to test the hypothesis that endogenous extracellular ATP has a role in the generation of the changes in cochlear mechanics induced by moderate intense sound exposure. Guinea pigs were exposed to either: (1) a perilymphatic administration of pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (PPADS, 1 mM), an ATP antagonist; (2) a moderately intense sound (6 kHz tone, 95 dB SPL, 15 min); or (3) a combination of the PPADS and the sound. The effects on the cubic distortion product otoacoustic emissions (DPOAEs; 2f(1)-f(2)) were monitored using three sets of equal level primaries (f(1) = 9.25 kHz, f(2) = 10.8 kHz, 2f(1)-f(2) = 7.7 kHz; f(1) =7.2 kHz, f(2) = 8.4 kHz, 2f(1)-f(2) = 6 kHz; f(1) = 5.55 kHz, f(2) = 6.5 kHz, 2f(1)-f(2) = 4.6 kHz). PPADS alone had no effect on the cubic DPOAEs monitored. The intense sound alone suppressed all three cubic DPOAEs. The combination of PPADS with the intense sound induced a suppression of the cubicDPOAEs that was equal to or greater than induced by the intense sound alone at f(2) = 10.8 kHz but was equal to or less than induced by the intense sound at f(2) = 8.4 and 6.5 kHz. After washing the PPADS out of the cochlea with artificial perilymph, all three cubic DPOAEs were suppressed less in the PPADS with intense sound treatment group than in the intense sound alonegroup. The PPADS appeared to provide protection from the intense sound. Results are consistent with the hypothesis that extracellular ATP is involvedin the changes in cochlear mechanics induced by moderately intense sound exposure. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 30/11/20 alle ore 16:48:11