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Titolo:
Successful symptomatic tazarotene treatment of juvenile familial obesity-associated acanthosis nigricans associated with insulin-resistance
Autore:
Weisshaar, E; Bonnekoh, B; Franke, I; Gollnick, H;
Indirizzi:
Otto Von Guericke Univ, Klin Dermatol & Venerol, D-39120 Magdeburg, Germany Otto Von Guericke Univ Magdeburg Germany D-39120 9120 Magdeburg, Germany
Titolo Testata:
HAUTARZT
fascicolo: 6, volume: 52, anno: 2001,
pagine: 499 - 503
SICI:
0017-8470(200106)52:6<499:SSTTOJ>2.0.ZU;2-6
Fonte:
ISI
Lingua:
GER
Soggetto:
PLAQUE PSORIASIS; DISEASE; GEL;
Keywords:
acanthosis nigricans; tazarotene; topical retinoids; pediatric dermatology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Weisshaar, E Otto Von Guericke Univ, Klin Dermatol & Venerol, Leipziger Str 44, D-39120Magdeburg, Germany Otto Von Guericke Univ Leipziger Str 44 Magdeburg Germany D-39120
Citazione:
E. Weisshaar et al., "Successful symptomatic tazarotene treatment of juvenile familial obesity-associated acanthosis nigricans associated with insulin-resistance", HAUTARZT, 52(6), 2001, pp. 499-503

Abstract

An 11-year-old boy suffering from morbid obesity since infancy developed at age 9 a progressive brown-black hyperpigmentated and hyperkeratotic eruption in the neck and axillary region with minor involvement of both groins. Based on this clinical picture, and confirmed by histopathology, we diagnosed acanthosis nigricans. Following a thorough endocrinological examination and because the patient's obese mother showed similar skin lesions, the disease was subclassified as a familial obesity-associated type of acanthosis nigricans associated with insulin resistance. In a right-left-comparison the affected skin of one body side was treated with tazarotene 0.05% versus urea 10%, once daily each. A great benefit for the tazarotene-treated over the opposite side could already be seen after three weeks which was also verified by dermatohistopathology. Three months after topical tazarotene treatment had been extended to both sides, the residual lesions were significantly improved. The highly satisfying, good result has been maintained up to now by a continuous topical retinoid treatment over 18 months, usually with an interval application regimen, i.e., 3 x per week.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:08:04