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Titolo:
Growth hormone (GH) and estradiol regulation of membrane-associated GH binding protein and GH receptors in GH releasing hormone transgenic mice
Autore:
Gonzalez, L; Sotelo, AI; Bartke, A; Turyn, D;
Indirizzi:
Univ Buenos Aires, Fac Farm & Bioquim, Dept Quim Biol, Inst Quim & Fisicoquim Biol,CONICET, RA-1113 Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina RA-1113 Aires, DF, Argentina So Illinois Univ, Sch Med, Dept Physiol, Carbondale, IL 62901 USA So Illinois Univ Carbondale IL USA 62901 hysiol, Carbondale, IL 62901 USA
Titolo Testata:
GROWTH HORMONE & IGF RESEARCH
fascicolo: 1, volume: 11, anno: 2001,
pagine: 34 - 40
SICI:
1096-6374(200102)11:1<34:GH(AER>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROLACTIN-BINDING; GONADAL-STEROIDS; EXPRESSING HUMAN; UP-REGULATION; MOUSE GH; RAT; SERUM; LIVER;
Keywords:
growth hormone; GH receptors; membrane-associated GHBP; estradiol; GHBP; GHRH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Turyn, D Univ Buenos Aires, Fac Farm & Bioquim, Dept Quim Biol, Inst Quim & Fisicoquim Biol,CONICET, Junin 956, RA-1113 Buenos Aires, DF, Argentina Univ Buenos Aires Junin 956 Buenos Aires DF Argentina RA-1113 ina
Citazione:
L. Gonzalez et al., "Growth hormone (GH) and estradiol regulation of membrane-associated GH binding protein and GH receptors in GH releasing hormone transgenic mice", GROWTH H I, 11(1), 2001, pp. 34-40

Abstract

eGrowth hormone (GH) releasing hormone (GHRH) transgenic mice were used toexamine the influence of GH on GH receptor (GHR) and membrane-associated GH binding protein (MA-GHBP) levels by means of specific radioimmunoassays and Western blot analysis, since MA-GHBP was described as the major constituent of somatogenic binding to liver membranes in mice. In transgenic animals, a 10-fold increment over normal values was found for hepatic somatogenicbinding that could be accounted for by a 3-4-fold increase in GHR and a-fold augmentation of MA-GHBP levels. The apparent molecular weight of MA-GHBPwas smaller than that of serum GHBP, a difference that was partially abolished by endoglycosidase F digestion. In vivo treatment of female mice with 17 beta -estradiol led to an unexpected down-regulation of MA-GHBP and GHR by 60-75% only in transgenic animals. MA-GHBP and GHR levels are strongly up-regulated by GH, although MA-GHBP up-regulation is much more important than that of GHR. (C) 2001 Harcourt Publishers Ltd.

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Documento generato il 28/09/20 alle ore 00:37:39