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Titolo:
Contrasting patterns of polymorphisms at the ABO-secretor gene (FUT2) and plasma alpha(1,3)fucosyltransferase gene (FUT6) in human populations
Autore:
Koda, Y; Tachida, H; Pang, H; Liu, YH; Soejima, M; Ghaderi, AA; Takenaka, O; Kimura, H;
Indirizzi:
Kurume Univ, Sch Med, Dept Forens Med, Div Human Genet, Kurume, Fukuoka 8300011, Japan Kurume Univ Kurume Fukuoka Japan 8300011 , Kurume, Fukuoka 8300011, Japan Kyushu Univ, Fac Sci, Dept Biol, Fukuoka 8128581, Japan Kyushu Univ Fukuoka Japan 8128581 Sci, Dept Biol, Fukuoka 8128581, Japan Shiraz Univ Med Sci, Dept Immunol, Shiraz, Iran Shiraz Univ Med Sci Shiraz Iran niv Med Sci, Dept Immunol, Shiraz, Iran Kyoto Univ, Primate Res Inst, Dept Biochem, Inuyama, Aichi 4840002, Japan Kyoto Univ Inuyama Aichi Japan 4840002 hem, Inuyama, Aichi 4840002, Japan
Titolo Testata:
GENETICS
fascicolo: 2, volume: 158, anno: 2001,
pagine: 747 - 756
SICI:
0016-6731(200106)158:2<747:CPOPAT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROUP ALPHA(1,2)FUCOSYLTRANSFERASE GENE; HUMAN LIPOPROTEIN-LIPASE; SIALYL-LEWIS-X; MOLECULAR-CLONING; DNA POLYMORPHISM; DETERMINES EXPRESSION; STATISTICAL TESTS; FUSION GENE; LOCUS FUT2; SEQUENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Kimura, H Kurume Univ, Sch Med, Dept Forens Med, Div Human Genet, Kurume, Fukuoka 8300011, Japan Kurume Univ Kurume Fukuoka Japan 8300011 Fukuoka 8300011, Japan
Citazione:
Y. Koda et al., "Contrasting patterns of polymorphisms at the ABO-secretor gene (FUT2) and plasma alpha(1,3)fucosyltransferase gene (FUT6) in human populations", GENETICS, 158(2), 2001, pp. 747-756

Abstract

The coding sequences (similar to1 kb) of FUT2 [ABO-Secretor type alpha (1,2)fucosyltransferase] and of FUT6 [plasma alpha (1,3)fucosyltransferase] were analyzed for allelic polymorphism by direct sequencing in five populations. The nucleotide diversities of FUT2 estimated from pairwise sequence differences were 0.0045, 0.0042, 0.0042, 0.0009, and 0.0008 in Africans, European-Africans, Iranians, Chinese, and Japanese, respectively. The nucleotidediversities of FUT6 were 0.0024, 0.0016, 0.0015, 0.0017, and 0.0020 in Africans, European-Africans, Iranians, Chinese, and Japanese, respectively. AtFUT2, excesses in pairwise sequence differences compared to the number of polymorphic sites as indicated by a significantly positive Tajima's D were observed in European-Africans and in Iranians. The data do not fit expectations of the equilibrium neutral model with an infinite number of sites. On the other hand, Tajima's D's at FUT6 in each of the five populations and atFUT2 in Africans, Chinese, and Japanese were not significantly different from zero. F-ST between the Asians and the others measured at FUT2 was higher than at FUT6. These results suggest that natural selection was responsible for the generation of the FUT2 polymorphism in European-Africans and in Iranians.

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Documento generato il 04/04/20 alle ore 15:15:06