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Titolo:
A transgenic insertion causing cryptorchidism in mice
Autore:
Overbeek, PA; Gorlov, IP; Sutherland, RW; Houston, JB; Harrison, WR; Boettger-Tong, HL; Bishop, CE; Agoulnik, AI;
Indirizzi:
Baylor Coll Med, Dept Obstet & Gynecol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 tet & Gynecol, Houston, TX 77030 USA Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Cellular Biol, Houston, TX 77030 USA Baylor Coll Med, Dept Urol, Houston, TX USA Baylor Coll Med Houston TX USA ylor Coll Med, Dept Urol, Houston, TX USA Baylor Coll Med, Dept Mol & Human Genet, Houston, TX USA Baylor Coll Med Houston TX USA , Dept Mol & Human Genet, Houston, TX USA
Titolo Testata:
GENESIS
fascicolo: 1, volume: 30, anno: 2001,
pagine: 26 - 35
SICI:
1526-954X(200105)30:1<26:ATICCI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-COUPLED RECEPTOR; TESTICULAR DESCENT; SIGNAL-TRANSDUCTION; EXPRESSION; GENE; MUTANT; INSL3;
Keywords:
cryptorchidism; infertility; insertional mutation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Agoulnik, AI Baylor Coll Med, Dept Obstet & Gynecol, 6550 Fannin St, Houston, TX 77030 USA Baylor Coll Med 6550 Fannin St Houston TX USA 77030 77030 USA
Citazione:
P.A. Overbeek et al., "A transgenic insertion causing cryptorchidism in mice", GENESIS, 30(1), 2001, pp. 26-35

Abstract

A distinctive feature of gonadal maturation in mammals is the movement to an extraabdominal location. Testicular descent is a complex, multistage process whereby the embryonic gonads migrate from their initial abdominal position to the scrotum. Failure in this process results in cryptorchidism, a frequent congenital birth defect in humans. We report here a new mouse transgenic insertional mutation, cryptorchidism with white spotting (crsp), Males homozygous for crsp exhibit a high intraabdominal position of the testes,associated with complete sterility, Heterozygous males have a wildtype phenotype, and homozygous females are fertile. Surgically descended testes in crsp/crsp males show normal spermatogenesis, Using FISH and genetic analyses, the transgenic insert causing the crsp mutation has been mapped to the distal part of mouse chromosome 5. Transgene integration resulted in a 550-kb deletion located upstream of the Brca2 gene. A candidate gene encoding a novel G protein-coupled receptor (Great) with an expression pattern suggesting involvement in testicular descent has been identified. genesis 30:26-35, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:08:24