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Titolo:
Variegated expression and delayed retinal pigmentation during development in transgenic mice with a deletion in the locus control region of the tyrosinase gene
Autore:
Gimenez, E; Giraldo, P; Jeffery, G; Montoliu, L;
Indirizzi:
CSIC, Ctr Nacl Biotecnol, Dept Mol & Cellular Biol, E-28049 Madrid, Spain CSIC Madrid Spain E-28049 ept Mol & Cellular Biol, E-28049 Madrid, Spain Univ Coll London, Inst Ophthalmol, London, England Univ Coll London London England ondon, Inst Ophthalmol, London, England
Titolo Testata:
GENESIS
fascicolo: 1, volume: 30, anno: 2001,
pagine: 21 - 25
SICI:
1526-954X(200105)30:1<21:VEADRP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITION-EFFECT VARIEGATION; CELL; EPITHELIUM; HETEROCHROMATIN; MOSAICISM; UPSTREAM; TRANSCRIPTION; MELANOCYTES; PATTERNS; ALBINISM;
Keywords:
position-effects; melanin; retinal pigment epithelium; YAC; mosaicism; LCR; variegation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Montoliu, L CSIC, Ctr Nacl Biotecnol, Dept Mol & Cellular Biol, Campus Cantoblanco, E-28049 Madrid, Spain CSIC Campus Cantoblanco Madrid Spain E-28049 49 Madrid, Spain
Citazione:
E. Gimenez et al., "Variegated expression and delayed retinal pigmentation during development in transgenic mice with a deletion in the locus control region of the tyrosinase gene", GENESIS, 30(1), 2001, pp. 21-25

Abstract

Deletion of the tyrosinase locus control region (LCR) in transgenic mice results in variegated expression in the skin. Here we investigate the pigmentation pattern of other tissues that express tyrosinase: iris, choroid, andretina in the same animals. A mosaic distribution of pigmentation appears in the iris and choroid. Interestingly, a markedly different mosaic patternis found in the retina, where central areas contain little or no melanin while pigmentation rises to normal levels towards periphery. Further, there is a temporal delay in the initiation and accumulation of pigment in retinal pigmented epithelium (RPE) cells during development, and patterns of adult retinal melanisation in these mice appear arrested at a stage found in early embryogenesis in wild-type mice. These results demonstrate that the tyrosinase LCR is needed for the correct establishment and maintenance of thisexpression domain throughout development, but particularly during the later stages of retinal melanisation. genesis 30:21-25, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:46:28