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Titolo:
Differential effects of calcium-dependent and calcium-independent phospholipase A(2) inhibitors on kainate-induced neuronal injury in rat hippocampalslices
Autore:
Lu, XR; Ong, WY; Halliwell, B; Horrocks, LA; Farooqui, AA;
Indirizzi:
Natl Univ Singapore, Dept Anat, Singapore 119260, Singapore Natl Univ Singapore Singapore Singapore 119260 ngapore 119260, Singapore Natl Univ Singapore, Dept Biochem, Singapore 119260, Singapore Natl Univ Singapore Singapore Singapore 119260 ngapore 119260, Singapore Ohio State Univ, Dept Mol & Cellular Biochem, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 lar Biochem, Columbus, OH 43210 USA
Titolo Testata:
FREE RADICAL BIOLOGY AND MEDICINE
fascicolo: 11, volume: 30, anno: 2001,
pagine: 1263 - 1273
SICI:
0891-5849(20010601)30:11<1263:DEOCAC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLOGICAL DISORDERS; FOREBRAIN ISCHEMIA; MODIFIED PROTEINS; MICE DEFICIENT; BRAIN; CULTURES; TISSUE; GLIA; LOCALIZATION; PURIFICATION;
Keywords:
phospholipase A(2); 4-hydroxynoneal; hippocampal slices; neurodegeneration; lipid peroxidation; excitotoxicity; free radicals;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Ong, WY Natl Univ Singapore, Dept Anat, Singapore 119260, Singapore Natl Univ Singapore Singapore Singapore 119260 119260, Singapore
Citazione:
X.R. Lu et al., "Differential effects of calcium-dependent and calcium-independent phospholipase A(2) inhibitors on kainate-induced neuronal injury in rat hippocampalslices", FREE RAD B, 30(11), 2001, pp. 1263-1273

Abstract

Brain tissue contains multiple forms of intracellular phospholipase A(2) (PLA(2)) activity that differ from each other in many ways including their response to specific inhibitors. The systemic administration of kainic acid to rats produces a marked increase in cPLA(2) activity in neurons and astrocytes. This is associated with increased lipid peroxidation as evidenced byaccumulation of 4-hydroxynonenal (4-HNE) modified proteins. The present study describes the effect of specific inhibitors of Ca2+ -dependent or Ca2+ -independent PLA(2) on kainite-induced excitotoxic injury in rat hippocampal slices. Specific inhibitors of Ca2+ -dependent PLA(2) prevented the decrease of a neuronal marker, GluR1, and increase in cPLA(2) and 4-HNE immunoreactivities in slices treated with kainate. This shows that cPLA(2) plays animportant role in kainite-induced neurotoxicity and that cPLA(2) inhibitors can be used to protect hippocampal slices from damage induced by kainate. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:13:21