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Titolo:
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
Autore:
Schafer, FQ; Buettner, GR;
Indirizzi:
Univ Iowa, Free Rad Res Inst, Iowa City, IA 52242 USA Univ Iowa Iowa CityIA USA 52242 ee Rad Res Inst, Iowa City, IA 52242 USA Univ Iowa, ESR Facil, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 Iowa, ESR Facil, Iowa City, IA 52242 USA
Titolo Testata:
FREE RADICAL BIOLOGY AND MEDICINE
fascicolo: 11, volume: 30, anno: 2001,
pagine: 1191 - 1212
SICI:
0891-5849(20010601)30:11<1191:REOTCA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANGANESE SUPEROXIDE-DISMUTASE; PROTEIN S-THIOLATION; METABOLIC OXIDATIVE STRESS; DNA-BINDING ACTIVITY; RAT-LIVER; HYDROGEN-PEROXIDE; GLUCOCORTICOID RECEPTOR; BUTHIONINE SULFOXIMINE; ADENINE-DINUCLEOTIDE; GLUCOSE DEPRIVATION;
Keywords:
glutathione; NADPH; nernst equation; reduction potentials; free radicals;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
177
Recensione:
Indirizzi per estratti:
Indirizzo: Schafer, FQ Univ Iowa, Free Rad Res Inst, EMRB 68, Iowa City, IA 52242 USAUniv Iowa EMRB 68 Iowa City IA USA 52242 wa City, IA 52242 USA
Citazione:
F.Q. Schafer e G.R. Buettner, "Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple", FREE RAD B, 30(11), 2001, pp. 1191-1212

Abstract

\Redox state is a term used widely in the research field of free radicals and oxidative stress. Unfortunately, it is used as a general term referringto relative changes that are not well defined or quantitated. In this review we provide a definition for the redox environment of biological fluids, cell organelles, cells, or tissue. We illustrate how the reduction potential of various redox couples can be estimated with the Nernst equation and show how pH and the concentrations of the species comprising different redox couples influence the reduction potential. We discuss how the redox state of the glutathione disulfide-glutathione couple (GSSG/2GSH) can serve as an important indicator of redox environment. There are many redox couples in acell that work together to maintain the redox environment; the GSSG/2GSH couple is the most abundant redox couple in a cell. Changes of the half-cellreduction potential (E-hc) of the GSSG/2GSH couple appear to correlate with the biological status of the cell: proliferation E-hc approximate to -240mV; differentiation E-hc approximate to -200 mV; or apoptosis E-hc approximate to -170 mV. These estimates can be used to more fully understand the redox biochemistry that results from oxidative stress. These are the first steps toward a new quantitative biology, which hopefully will provide a rationale and understanding of the cellular mechanisms associated with cell growth and development, signaling, and reductive or oxidative stress. (C) 2001Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:46:02