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Titolo:
Catalytic activity of ADAM28
Autore:
Howard, L; Zheng, YF; Horrocks, M; Maciewicz, RA; Blobel, C;
Indirizzi:
Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Cellular Biochem & Biophys Program, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New YorkNY USA 10021 New York, NY 10021 USA Weill Grad Sch Med Sci, Grad Program Physiol Biophys & Mol Med, New York, NY 10021 USA Weill Grad Sch Med Sci New York NY USA 10021 Med, New York, NY 10021 USA AstraZeneca Pharmaceut, Resp & Inflammat Res Area, Macclesfield SK10 4TG, Cheshire, England AstraZeneca Pharmaceut Macclesfield Cheshire England SK10 4TG re, England
Titolo Testata:
FEBS LETTERS
fascicolo: 1, volume: 498, anno: 2001,
pagine: 82 - 86
SICI:
0014-5793(20010601)498:1<82:CAOA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; CONVERTING-ENZYME TACE; DISINTEGRIN-METALLOPROTEASE; BIOCHEMICAL-CHARACTERIZATION; INTRACELLULAR MATURATION; SECRETASE CLEAVAGE; TISSUE INHIBITORS; PROTEIN; PRECURSOR; TIMP-3;
Keywords:
ADAM; metalloprotease disintegrin; metalloproteinase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Blobel, C Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Cellular Biochem & Biophys Program, POB 368,1275 York Ave, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr POB 368,1275 York Ave New York NY USA 10021
Citazione:
L. Howard et al., "Catalytic activity of ADAM28", FEBS LETTER, 498(1), 2001, pp. 82-86

Abstract

ADAMs are membrane-anchored glycoproteins containing a disintegrin and metalloprotease domain that have important roles in fertilization, development, and diseases such as Alzheimer's dementia, Here we present the first evidence for catalytic activity of ADAM28, a protein that is highly expressed in the epididymis and lymphocytes. Recombinant ADAM28 cleaves myelin basic protein at two sites. The catalytic activity of ADAM28 is not sensitive to tissue inhibitors of metalloproteases 1 and 2, but can be abolished by a mutation in the catalytic site. Catalytically active ADAM28 will be valuable for further studies of its role in sperm maturation and lymphocyte function,(C) 2001 Published by Elsevier Science B,V, on behalf of the Federation ofEuropean Biochemical Societies.x

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:29:19