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Titolo:
Statine-derived tetrapeptide inhibitors of beta-secretase - Elan Pharm., Inc.: WO0077030
Autore:
;
Titolo Testata:
EXPERT OPINION ON THERAPEUTIC PATENTS
fascicolo: 6, volume: 11, anno: 2001,
pagine: 1047 - 1050
SICI:
1354-3776(200106)11:6<1047:STIOB->2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; ALZHEIMERS-DISEASE; ASPARTYL PROTEASE; CLEAVAGE; BACE2; PATHOGENESIS; TERMINUS; PEPTIDES; BRAIN; SITE;
Keywords:
beta-secretase; beta-secretase inhibitors; gamma-secretase; Alzheimer disease; amyloid beta-peptide; amyloid precursor protein (APP); aspartyl protease; beta-site APP cleaving enzyme (BACE);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
EXPERT OP T, 11(6), 2001, pp. 1047-1050

Abstract

Alzheimer's disease (AD) is characterised by the accumulation of amyloid beta -peptide (A beta) within senile plaques in the brain. beta -secretase is one of the enzymes necessary for the production of amyloid P-peptide fromthe amyloid precursor protein (APP), the other being gamma -secretase. beta -Secretase was recently characterised as a novel aspartyl protease. Statine-derived tetrapeptide inhibitors of this enzyme, described in this patent, may have therapeutic applications in AD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:34:02