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Titolo:
Nitric oxide therapy for cardiovascular disease
Autore:
Laight, DW;
Indirizzi:
Univ Portsmouth, Sch Pharm & Biomed Sci, Portsmouth PO1 2DT, Hants, England Univ Portsmouth Portsmouth Hants England PO1 2DT PO1 2DT, Hants, England
Titolo Testata:
EXPERT OPINION ON THERAPEUTIC PATENTS
fascicolo: 6, volume: 11, anno: 2001,
pagine: 999 - 1005
SICI:
1354-3776(200106)11:6<999:NOTFCD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRATE TOLERANCE; ENDOTHELIAL DYSFUNCTION; SUPEROXIDE ANION; L-ARGININE; IN-VIVO; ASYMMETRIC DIMETHYLARGININE; GLYCERYL TRINITRATE; VITAMIN-C; MECHANISM; NITROGLYCERIN;
Keywords:
L-arginine; angiotensin II; angiotensin converting enzyme; antioxidants; atherosclerosis; nitrate tolerance; nitric oxide synthase (NOS); nitrovasodilators; NO-mimetics; nutraceuticals; organic nitrates; PDEV; soluble guanylate cyclase; superoxide anion; type 2 diabetes mellitus;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Laight, DW Univ Portsmouth, Sch Pharm & Biomed Sci, White Swan Rd, Portsmouth PO1 2DT, Hants, England Univ Portsmouth White Swan Rd Portsmouth Hants England PO1 2DT
Citazione:
D.W. Laight, "Nitric oxide therapy for cardiovascular disease", EXPERT OP T, 11(6), 2001, pp. 999-1005

Abstract

Endothelium-derived NO is acknowledged as a key mediator of cardiovascularhomeostasis. Indeed, an impairment in endothelial function resulting in limited NO bioavailability may contribute to a raft of vascular pathologies while a failure of peripheral 'nitrergic' neurovasodilator tone is implicated in erectile dysfunction. In addition to the established NO therapy exemplified by the use of nitrovasodilators, the endogenous NO pathway can now betherapeutically modulated to optimise endothelial or peripheral neuronal vasodilator function by inhibiting PDEV. A similar modulation of the NO pathway may also be clinically viable through the supplementation of precursorsand cofactors of NO synthesis, the upregulation of endothelial NO synthase(eNOS) and the transfection of NOS genes to the vasculature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 21:49:37