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Titolo:
p53 as a drug target in cancer therapy
Autore:
Chene, P;
Indirizzi:
Novartis, Dept Oncol, CH-4002 Basel, Switzerland Novartis Basel Switzerland CH-4002 ept Oncol, CH-4002 Basel, Switzerland
Titolo Testata:
EXPERT OPINION ON THERAPEUTIC PATENTS
fascicolo: 6, volume: 11, anno: 2001,
pagine: 923 - 935
SICI:
1354-3776(200106)11:6<923:PAADTI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; DNA-BINDING FUNCTION; SELECTIVELY-REPLICATING ADENOVIRUS; SQUAMOUS-CELL CARCINOMA; HUMAN BREAST-CANCER; WILD-TYPE; MUTANT P53; IN-VIVO; LUNG-CANCER; MUTATED P53;
Keywords:
p53; antisense oligonucleotide; cancer; gene therapy; immunotherapy; mdm2;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
151
Recensione:
Indirizzi per estratti:
Indirizzo: Chene, P Novartis, Dept Oncol, K125 420, CH-4002 Basel, Switzerland Novartis K125 420 Basel Switzerland CH-4002 2 Basel, Switzerland
Citazione:
P. Chene, "p53 as a drug target in cancer therapy", EXPERT OP T, 11(6), 2001, pp. 923-935

Abstract

The tumour suppressor gene p53 is mutated in various human cancers. The loss of p53 function predisposes to cancer and it has been suggested that theefficacy of chemotherapy and radiotherapy depends on the presence of a functional p53. The central role of p53 in cancer has stimulated intense research activity and various strategies to identify new anticancer compounds that modulate the p53 pathway are currently under investigation. These approaches rely on very different principles. Some involve replacement gene therapy where p53 is reintroduced into tumour cells or engineered viruses that selectively eliminate cells with an altered p53 pathway. Others are based onthe synthesis of new molecules that stabilise the structure of the mutant proteins or that activate either wild type or mutant proteins. Finally, others use antibodies that specifically interact with tumour cells. In this review, recent patent applications and the progress currently being made on these different approaches are analysed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 01:07:08