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Titolo:
Continuity with ganglionic eminence modulates interkinetic nuclear migration in the neocortical pseudostratified ventricular epithelium
Autore:
Miyama, S; Takahashi, T; Goto, T; Bhide, PG; Caviness, VS;
Indirizzi:
Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA 02129 USA Massachusetts Gen Hosp Charlestown MA USA 02129 Charlestown, MA 02129 USA Harvard Univ, Sch Med, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 vard Univ, Sch Med, Boston, MA 02114 USA Keio Univ, Sch Med, Dept Pediat, Tokyo, Japan Keio Univ Tokyo JapanKeio Univ, Sch Med, Dept Pediat, Tokyo, Japan
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 2, volume: 169, anno: 2001,
pagine: 486 - 495
SICI:
0014-4886(200106)169:2<486:CWGEMI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE CORPUS STRIATUM; MURINE CEREBRAL WALL; CELL-CYCLE KINETICS; DNA-DAMAGE; ZONE; CHECKPOINTS; BEHAVIOR; CORTEX; PATTERNS; MARKER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Bhide, PG Massachusetts Gen Hosp, Dept Neurol, 149,13th St, Charlestown, MA 02129 USA Massachusetts Gen Hosp 149,13th St Charlestown MA USA 02129 USA
Citazione:
S. Miyama et al., "Continuity with ganglionic eminence modulates interkinetic nuclear migration in the neocortical pseudostratified ventricular epithelium", EXP NEUROL, 169(2), 2001, pp. 486-495

Abstract

Cells of the pseudostratified ventricular epithelium (PVE) undergo interkinetic nuclear migration whereby position of cell soma with nucleus is systematically dependent upon cell cycle phase. We examined if the interkinetic nuclear migration in the neopallial PVE is influenced by tissue continuity with the ganglionic eminence (GE) of the basal forebrain in explants from embryonic day 13 mice. We found that when continuity between the neopallial wall and the GE is intact, some neopallial PVE cells discontinue interkinetic nuclear migration following S-phase and upon entry into G2-phase, The somata and nuclei of those cells shift outward from the S-phase zone toward the subventricular and the intermediate zones, The outward migration of post-S-phase cells is observed only in the lateral region of the cerebral wall,which is closely adjacent to the GE, but not in the medial reson, and onlywhen tissue continuity with GE is maintained. We suggest that the outward moving PVE cells seed the secondary proliferative population (SPP) and thatexit of the SPP seeding cells occurs in GB-phase, The phenomenon recapitulates similar migratory behavior of neopallial PVE cells in vivo and appearsto represent a "choice" between two opposing options available to post-S-phase cells of the PVE. The choice appears to be imposed by mechanisms dependent upon continuity with the GE. We conclude that GE, and/or other adjacent basal forebrain structures, modulates interkinetic nuclear migration in the neopallial PVE. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 11:18:13