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Titolo:
Modifications by sumatriptan and acetylcholine of nitric oxide-mediated neurogenic dilatation in dog cerebral arteries
Autore:
Ayajiki, K; Fujioka, H; Noda, K; Okamura, T; Toda, N;
Indirizzi:
Nippon Shinyaku Co Ltd, Res Labs, Minami Ku, Kyoto 6018550, Japan Nippon Shinyaku Co Ltd Kyoto Japan 6018550 nami Ku, Kyoto 6018550, Japan Shiga Univ Med Sci, Dept Pharmacol, Otsu, Shiga 5202192, Japan Shiga Univ Med Sci Otsu Shiga Japan 5202192 l, Otsu, Shiga 5202192, Japan
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 420, anno: 2001,
pagine: 67 - 72
SICI:
0014-2999(20010518)420:1<67:MBSAAO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITROXIDERGIC NERVE FUNCTION; ISOLATED BASILAR ARTERY; VASODILATOR NERVE; INHIBITION; RECEPTOR; MIGRAINE; 5-HT1B; STIMULATION; ACTIVATION; MECHANISM;
Keywords:
sumatriptan; acetylcholine; nitroxidergic nerve, nitrergic; cerebral artery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Toda, N Nippon Shinyaku Co Ltd, Res Labs, Minami Ku, Kyoto 6018550, Japan Nippon Shinyaku Co Ltd Kyoto Japan 6018550 Kyoto 6018550, Japan
Citazione:
K. Ayajiki et al., "Modifications by sumatriptan and acetylcholine of nitric oxide-mediated neurogenic dilatation in dog cerebral arteries", EUR J PHARM, 420(1), 2001, pp. 67-72

Abstract

Canine cerebral arterial strips denuded of endothelium responded to nicotine and transmural electrical stimulation with relaxations, which were abolished by NG-nitro-L-arginine and methylene blue. Magnitudes of relaxation did not differ in the arteries contracted with prostaglandin F2 alpha and sumatriptan, an effective therapeutic of migraine. Sumatriptan concentration-dependently contracted the arteries responding to 2 Hz stimulation with persistent relaxations, and the concentration of this 5-HT1B/(1D)/(1F) receptoragonist to overcome the relaxation averaged 1.06 x 10(-7) M. Acetylcholineinhibited the response to nerve stimulation due possibly to its action on prejunctional nitroxidergic nerves; the inhibition did not differ in the arteries contracted with prostaglandin F-2 alpha and K+. It appears that sumatriptan does not interfere with the release of nitric oxide from nerves butcounteracts the neurogenic relaxation by functional antagonistic action onsmooth muscle. Prejunctional inhibition by muscarinic receptor activation is unlikely associated with opening of neuronal K+ channels. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 21:56:17