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Titolo:
Stimulatory effects of nitric oxide donors on gastric acid secretion in isolated mouse stomach
Autore:
Hasebe, K; Horie, S; Komasaka, M; Yano, S; Watanabe, K;
Indirizzi:
Chiba Univ, Fac Pharmaceut Sci, Dept Drug Evaluat & Toxicol Sci, Chem Pharmacol Lab, Chiba 2638522, Japan Chiba Univ Chiba Japan 2638522 Chem Pharmacol Lab, Chiba 2638522, Japan Chiba Univ, Fac Pharmaceut Sci, Dept Mol Pharmacol & Pharmacotherapeut, Chiba 2638522, Japan Chiba Univ Chiba Japan 2638522 & Pharmacotherapeut, Chiba 2638522, Japan
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 420, anno: 2001,
pagine: 159 - 164
SICI:
0014-2999(20010525)420:2-3<159:SEONOD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNTHASE INHIBITOR; HISTAMINE-RELEASE; WHOLE STOMACH; CELLS; MODULATION; FAMOTIDINE; OUABAIN; RATS;
Keywords:
nitric oxide (NO); gastric acid secretion; histamine; enterochromaffin-like cell; stomach, isolated, mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Horie, S Chiba Univ, Fac Pharmaceut Sci, Dept Drug Evaluat & Toxicol Sci, Chem Pharmacol Lab, Chiba 2638522, Japan Chiba Univ Chiba Japan 2638522 rmacol Lab, Chiba 2638522, Japan
Citazione:
K. Hasebe et al., "Stimulatory effects of nitric oxide donors on gastric acid secretion in isolated mouse stomach", EUR J PHARM, 420(2-3), 2001, pp. 159-164

Abstract

We previously reported on the stimulatory role of endogenous nitric oxide (NO) in gastric acid secretion. In the present study, we investigated the effects of NO donors on acid secretion in isolated mouse stomach. Nitroprusside (100 muM-1 mM) inhibited the gastric acid secretion induced by histamine (500 muM) in a concentration-dependent manner. In addition, nitroprussideabolished the acid secretion induced by bethanechol (100 muM) and by electrical stimulation (10 Hz) of the vagus nerve. On the other hand, nitroprusside, 75 muM, which did not affect the acid secretion induced by histamine, itself elicited an increase in acid secretion. The acid secretion induced by 75 ELM nitroprusside was inhibited by 10 muM famotidine, a histamine H-2 receptor antagonist. These results suggest that NO donors at high doses acton gastric parietal cells, resulting in inhibition of the stimulated acid secretion, and, at lower doses, facilitate histamine release from histamine-containing cells, leading to the increased acid secretion. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:02:10