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Titolo:
FK506 (tacrolimus) increases rat alpha(1)-acid glycoprotein expression in liver and primary cultured hepatocytes
Autore:
Shimoishi, K; Kai, H; Kabu, K; Komori, T; Maruyama, T; Otagiri, M;
Indirizzi:
Kumamoto Univ, Fac Pharmaceut Sci, Kumamoto 8620973, Japan Kumamoto Univ Kumamoto Japan 8620973 maceut Sci, Kumamoto 8620973, Japan
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 420, anno: 2001,
pagine: 91 - 95
SICI:
0014-2999(20010525)420:2-3<91:F(IRAG>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ALPHA-1-ACID GLYCOPROTEIN; ACUTE-PHASE RESPONSE; GENE-EXPRESSION; INTERLEUKIN-1; INDUCTION; BINDING; LIGANDS; CELLS;
Keywords:
FK506 (tacrolimus); alpha(1)-acid glycoprotein; glucocorticoid; FK506-binding protein (FKBP);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Otagiri, M Kumamoto Univ, Fac Pharmaceut Sci, 5-1 Oe Honmachi, Kumamoto 8620973, Japan Kumamoto Univ 5-1 Oe Honmachi Kumamoto Japan 8620973 73, Japan
Citazione:
K. Shimoishi et al., "FK506 (tacrolimus) increases rat alpha(1)-acid glycoprotein expression in liver and primary cultured hepatocytes", EUR J PHARM, 420(2-3), 2001, pp. 91-95

Abstract

FK506 (tacrolimus) (10 mg/kg. s.c., 5 days) increased rat alpha (1)-acid glycoprotein (AGP) in serum and AGP mRNA in liver. FK506 potentiated the dexamethasone-increased AGP expression in primary cultured hepatocytes. In theluciferase promoter assay. FK506 potentiated the dexamethasone-increased promoter activity of the AGP gene in cultured rat hepatocytes, although FK506 alone had no effect on its activity. The combined effect of FK506 and dexamethasone was diminished by glucocorticoid responsive element (GRE) deletion and mutation or by an anti-glucocorticoid. These results indicated that FK506 causes the transcriptional induction of AGP, at least in part, via a glucocorticoid-mediated mechanism. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 11:45:46