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Titolo:
Typical antipsychotics exhibit inverse agonist activity at rat dopamine D1-like receptors expressed in Sf9 cells
Autore:
Martin, MW; Scott, AW; Johnston, DE; Griffin, S; Luedtke, RR;
Indirizzi:
Univ N Texas, Hlth Sci Ctr, Dept Pharmacol & Neurosci, Ft Worth, TX 76107 USA Univ N Texas Ft Worth TX USA 76107 col & Neurosci, Ft Worth, TX 76107 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 420, anno: 2001,
pagine: 73 - 82
SICI:
0014-2999(20010525)420:2-3<73:TAEIAA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TERNARY COMPLEX MODEL; D1; ANTAGONISTS; PROTEIN; CLONING; COCAINE; ACTIVATION; SUBTYPES; RETINA; CORTEX;
Keywords:
adenylyl cyclase stimulation; antipyschotic; baculovirus expression; dopamine D1 receptor; dopamine receptor; inverse agonist;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Luedtke, RR Univ N Texas, Hlth Sci Ctr, Dept Pharmacol & Neurosci, 3500 Camp Bowie Blvd, Ft Worth, TX 76107 USA Univ N Texas 3500 Camp Bowie Blvd Ft Worth TX USA 76107 07 USA
Citazione:
M.W. Martin et al., "Typical antipsychotics exhibit inverse agonist activity at rat dopamine D1-like receptors expressed in Sf9 cells", EUR J PHARM, 420(2-3), 2001, pp. 73-82

Abstract

The baculovirus system has been used to express the rat dopamine D1 receptors in Spodoptera frugiperda (Sf9) cells. A panel of typical antipsychoticsincluding, alpha -flupenthixol, fluphenazine and thioridizine were found to inhibit dopamine-dependent stimulation of adenylyl cyclase. However, these compounds were also found to inhibit adenylyl cyclase activity in the absence of agonist in Sf9 cells expressing dopamine D1-like receptors. Therefore, these nonselective dopamine receptor compounds displayed negative intrinsic or inverse agonist activity. None of the compounds tested were neutralantagonists. (C) 2001 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 10:44:42