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Titolo:
Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1
Autore:
Ogawa, K; Sun, J; Taketani, S; Nakajima, O; Nishitani, C; Sassa, S; Hayashi, N; Yamamoto, M; Shibahara, S; Fujita, H; Igarashi, K;
Indirizzi:
Hiroshima Univ, Sch Med, Dept Biochem, Minami Ku, Hiroshima 7348551, JapanHiroshima Univ Hiroshima Japan 7348551 nami Ku, Hiroshima 7348551, Japan Hokkaido Univ, Sch Med, Lab Environm Biol, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan Tohoku Univ, Sch Med, Dept Mol Biol & Appl Physiol, Sendai, Miyagi 9808575, Japan Tohoku Univ Sendai Miyagi Japan 9808575 ol, Sendai, Miyagi 9808575, Japan Kyoto Inst Technol, Kyoto 6008585, Japan Kyoto Inst Technol Kyoto Japan 6008585 nst Technol, Kyoto 6008585, Japan Yamagata Univ, Res Lab Mol Genet, Yamagata 9909585, Japan Yamagata Univ Yamagata Japan 9909585 Mol Genet, Yamagata 9909585, Japan Tohoku Univ, Sch Med, Dept Biochem, Sendai, Miyagi 9808575, Japan Tohoku Univ Sendai Miyagi Japan 9808575 em, Sendai, Miyagi 9808575, Japan Univ Tsukuba, Ctr Tsukuba Adv Res Alliance, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Univ Tsukuba, Inst Basic Med, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Rockefeller Univ, New York, NY 10021 USA Rockefeller Univ New York NY USA10021 eller Univ, New York, NY 10021 USA
Titolo Testata:
EMBO JOURNAL
fascicolo: 11, volume: 20, anno: 2001,
pagine: 2835 - 2843
SICI:
0261-4189(20010601)20:11<2835:HMDOMR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELTA-AMINOLEVULINATE SYNTHASE; MESSENGER-RNA; GENE-EXPRESSION; ERYTHROLEUKEMIA-CELLS; CHROMOSOME 21Q22.1; EIF-2-ALPHA KINASE; OXYGENASE-1 GENE; PROTEINS; FAMILY; YEAST;
Keywords:
heme; Maf; NF-E2; transcription repression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Igarashi, K Hiroshima Univ, Sch Med, Dept Biochem, Minami Ku, Kasumi 1-2-3, Hiroshima 7348551, Japan Hiroshima Univ Kasumi 1-2-3 Hiroshima Japan 7348551 51, Japan
Citazione:
K. Ogawa et al., "Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1", EMBO J, 20(11), 2001, pp. 2835-2843

Abstract

Heme controls expression of genes involved in the synthesis of globins andheme, The mammalian transcription factor Bach1 functions as a repressor ofthe Maf recognition element (MARE) by forming antagonizing hetero-oligomers with the small Maf family proteins. We show here that heme binds specifically to Bach1 and regulates its DNA-hinding activity. Deletion studies demonstrated that a heme-binding region of Bach1 is confined within its C-terminal region that possesses four dipeptide cysteine-proline (CP) motifs. Mutations in all of the CP motifs of Bach1 abolished its interaction with heme. The DNA-binding activity of Bach1 as a MafK hetero-oligomer was markedly inhibited by heme in gel mobility shift assays. The repressor activity of Bach1 was lost upon addition of hemin in transfected cells, These results suggest that increased levels of heme inactivate the repressor Bach1, resulting in induction of a host of genes with MAREs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:22:38