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Titolo:
Anorexia nervosa and bulimia nervosa: An appraisal
Autore:
Sharma, A;
Indirizzi:
Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Patiala 147002, Punjab, India Punjabi Univ Patiala Punjab India 147002 s, Patiala 147002, Punjab, India
Titolo Testata:
DRUGS OF TODAY
fascicolo: 4, volume: 37, anno: 2001,
pagine: 229 - 236
SICI:
0025-7656(200104)37:4<229:ANABNA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
EATING DISORDERS; ADRENAL-FUNCTION; NEUROPEPTIDE-Y; FOLLOW-UP; WEIGHT; LEPTIN; UNDERWEIGHT; POPULATION; CORRELATE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Sharma, A Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Patiala 147002, Punjab, India Punjabi Univ Patiala Punjab India 147002 147002, Punjab, India
Citazione:
A. Sharma, "Anorexia nervosa and bulimia nervosa: An appraisal", DRUGS TODAY, 37(4), 2001, pp. 229-236

Abstract

Anorexia nervosa (AN) and bulimia nervosa (BN) are eating disorders characterized by an aberrant pattern of eating behavior, relentless pursuit of thinness, an intense fear about weight gain and an altered perception of bodyshape. The pathobiology of eating disorders is complex. Several social, psychological and developmental phenomena are proposed to contribute to the etiology of eating disorders. The role of neuropeptide Y, corticotropin releasing hormone and leptin has also been investigated to understand the pathogenesis of eating disorders. However, most of the neuropeptide alterations noted in eating disorders are secondary to starvation. Several nonpharmacological approaches such as cognitive and behavior-based therapy and interpersonal therapy have been developed to assist weight gain and to modify the behavioral impairment associated with eating disorders. Pharmacotherapy serves as an adjunct in AN, whereas it plays a more significant role in the management of BN. Antidepressants are effective in a limited number of AN patients with comorbid depression. On the other hand, the efficacy of fluoxetine in BN patients in reducing the frequency of binge eating and in the severity of behavioral abnormalities is quite impressive. Several adjunct therapies such as prokinetics and anxiolytics have also been used in AN and BN toassist eating behavior. An insight into genetic and neurochemical abnormalities occurring in eating disorders will help to find better therapeutic agents for these disorders, (C) 2001 Prous Science. Ail rights reserved.

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Documento generato il 12/07/20 alle ore 09:17:46