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Titolo:
Effects of cocaine prior to and during bupropion maintenance in cocaine-abusing volunteers
Autore:
Oliveto, A; McCance-Katz, FE; Singha, A; Petrakis, I; Hameedi, F; Kosten, TR;
Indirizzi:
VA Connecticut Healthcare Syst, Psychiat Serv, W Haven, CT 06516 USA VA Connecticut Healthcare Syst W Haven CT USA 06516 W Haven, CT 06516 USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06519 USA Yale Univ New Haven CT USA 06519 , Dept Psychiat, New Haven, CT 06519 USA
Titolo Testata:
DRUG AND ALCOHOL DEPENDENCE
fascicolo: 2, volume: 63, anno: 2001,
pagine: 155 - 167
SICI:
0376-8716(20010701)63:2<155:EOCPTA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASAL EXTRACELLULAR DOPAMINE; INTRAVENOUS COCAINE; DISCRIMINATIVE-STIMULUS; SMOKED COCAINE; INTRANASAL COCAINE; NUCLEUS-ACCUMBENS; PHARMACOLOGICAL CHARACTERIZATION; DESIPRAMINE MAINTENANCE; DEPRESSED-PATIENTS; ANTI-DEPRESSANTS;
Keywords:
cocaine; bupropion; pharmacotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Oliveto, A VA Connecticut Healthcare Syst, Psychiat Serv, Bldg 36,950 Campbell Ave, WHaven, CT 06516 USA VA Connecticut Healthcare Syst Bldg 36,950 Campbell Ave W Haven CT USA 06516
Citazione:
A. Oliveto et al., "Effects of cocaine prior to and during bupropion maintenance in cocaine-abusing volunteers", DRUG AL DEP, 63(2), 2001, pp. 155-167

Abstract

The effects of cocaine were examined prior to and during bupropion maintenance in nonopioid-dependent cocaine abusers. Prior to bupropion maintenance, subjects underwent an experimental session during which repeated cocaine doses (0, 50, 100 mg/70 kg) were administered intranasally. Then subjects were maintained on bupropion (150 and 300 mg per day) and underwent experimental sessions as before. Cocaine, regardless of bupropion, produced dose-related increases in several stimulant-like self-reports, performance and cardiovascular measures. Bupropion decreased POMS ratings of friendliness and vigor, regardless of cocaine dose. Bupropion enhanced and attenuated cocaine-induced increases in ratings on the LSD and BG subscales of the ARCI, respectively. These results suggest that bupropion does not alter the acute subjective or cardiovascular effects of cocaine in a robust manner. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:20:18