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Titolo:
Dose-dependent conjugation of sulfobromophthalein and hepatic transit timein bile fistula rats - Role of the microtubule-dependent vesicle pathway
Autore:
Tazuma, S; Horikawa, K; Ochi, H; Nishioka, T; Sunami, Y; Yasumiba, S; Asamoto, Y; Tsuboi, K; Nakai, K; Sakomoto, M; Kanno, K; Yamaguchi, A; Numata, Y; Chayama, K;
Indirizzi:
Hiroshima Univ, Sch Med, Dept Internal Med 1, Minami Ku, Hiroshima 7348551, Japan Hiroshima Univ Hiroshima Japan 7348551 nami Ku, Hiroshima 7348551, Japan
Titolo Testata:
DIGESTIVE DISEASES AND SCIENCES
fascicolo: 6, volume: 46, anno: 2001,
pagine: 1285 - 1289
SICI:
0163-2116(200106)46:6<1285:DCOSAH>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BILIARY LIPID STRUCTURES; ORGANIC-ANIONS; CHOLESTEROL SECRETION; ASSOCIATION; INHIBITION; BILIRUBIN; TRANSPORT;
Keywords:
bile acid; biliary lipid; organic anion; vesicular transport;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Tazuma, S Hiroshima Univ, Sch Med, Dept Internal Med 1, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan Hiroshima Univ 1-2-3 Kasumi Hiroshima Japan 7348551 8551, Japan
Citazione:
S. Tazuma et al., "Dose-dependent conjugation of sulfobromophthalein and hepatic transit timein bile fistula rats - Role of the microtubule-dependent vesicle pathway", DIG DIS SCI, 46(6), 2001, pp. 1285-1289

Abstract

Sulfobromophthalein (BSP) is selectively taken up by the liver and secreted into the bile as unconjugated and conjugated forms. Our previous study demonstrated that unconjugated BSP, but not conjugated BSP, caused the dissociation of biliary lipid secretion from that of bile acids, suggesting that the hepatic BSP conjugation rate partly regulated biliary lipid secretion. To evaluate the mechanisms through which biliary lipid secretion is regulated by exogenous organic anions, we intravenously administered BSP to male Sprague-Dawley rats at various doses either continuously or as a bolus. Thenthe relationship of the dose of BSP to its conjugation rate, hepatic transit time, and biliary lipid secretion was determined. BSP decreased biliary secretion of cholesterol and phospholipids in a dose-dependent manner without affecting bile acid secretion. In contrast, the proportion of conjugatedBSP in bile was associated with the dose. Although the serum clearance of BSP after bolus infusion was constant regardless of the dose administered (50 or 200 nmol/100 g), BSP secretion was delayed with increasing doses: unconjugated BSP was secreted predominantly in the early phase (0-15 min afterbolus injection), and conjugated BSP was the predominant form in the late phase (15-30 min). Pretreatment with colchicine reduced the conjugation rate and hepatic transit time of BSP, suggesting that the microtubule-dependent vesicle pathway plays a role in biliary excretion and conjugation of BSP. We conclude that biliary lipid secretion is influenced by organic anions with an affinity for bile acids such as BSP and that this effect is dependent upon the hepatic metabolic rate, i.e., conjugation rate. The hepatic transit time also plays a key role in this process by influencing metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 02:17:43