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Titolo:
Role of substance P and calcitonin gene-related peptide in acid-induced augmentation of opossum esophageal blood flow
Autore:
Feldman, MJ; Morris, GP; Paterson, WG;
Indirizzi:
Queens Univ, Div Gastroenterol, Kingston, ON, Canada Queens Univ KingstonON Canada , Div Gastroenterol, Kingston, ON, Canada Queens Univ, Dept Biol, Gastrointestinal Dis Res Unit, Kingston, ON, Canada Queens Univ Kingston ON Canada stinal Dis Res Unit, Kingston, ON, Canada
Titolo Testata:
DIGESTIVE DISEASES AND SCIENCES
fascicolo: 6, volume: 46, anno: 2001,
pagine: 1194 - 1199
SICI:
0163-2116(200106)46:6<1194:ROSPAC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED HISTAMINE-RELEASE; MAST-CELLS; NITRIC-OXIDE; SMALL-INTESTINE; NEURONS; STOMACH; SKIN; NK1;
Keywords:
esophagus; blood flow; substance P; calcitonin gene-related peptide; mast cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Paterson, WG Hop Hotel Dieu, 166 Brock St, Kingston, ON K7L 5G2, Canada Hop Hotel Dieu 166 Brock St Kingston ON Canada K7L 5G2 Canada
Citazione:
M.J. Feldman et al., "Role of substance P and calcitonin gene-related peptide in acid-induced augmentation of opossum esophageal blood flow", DIG DIS SCI, 46(6), 2001, pp. 1194-1199

Abstract

Increased esophageal blood flow may protect against damaging refluxed gastric juices. We have shown that mast cells, histamine, and nitric oxide increase esophageal blood Row in the opossum during acid perfusion. This study examined the roles of substance P and calcitonin gene-related peptide on acid-induced hyperemia and whether the effects of substance P are mediated bymast cells. The opossum distal esophagus was perfused with saline, acid, or capsaicin while blood flow and histamine release were determined. Neuropeptides and neurokinin antagonists were administered parenterally. Only acidor calcitonin gene-related peptide (not substance P or capsaicin) significantly increased blood flow, which was prevented by neurokinin or calcitonin-gene-related peptide antagonists. Acid, substance P, and capsaicin all increased histamine release. Pretreatment with neurokinin antagonists did not affect acid-induced histamine release. We conclude that calcitonin-gene-related peptide is an important mediator of acid-induced esophageal hyperemia,while substance P plays an indirect role.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 14:53:55