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Titolo:
Influence of a combination of herbs on appetite suppression and weight loss in rats
Autore:
Talpur, NA; Echard, BW; Manohar, V; Preuss, HG;
Indirizzi:
Georgetown Univ, Med Ctr, Dept Med, Div Renal, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 v Renal, Washington, DC 20007 USA
Titolo Testata:
DIABETES OBESITY & METABOLISM
fascicolo: 3, volume: 3, anno: 2001,
pagine: 181 - 185
SICI:
1462-8902(200106)3:3<181:IOACOH>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; OBESE PATIENTS; HYPERTENSION; FENFLURAMINE; REDUCTION; OVERWEIGHT; EFFICACY; DISEASE;
Keywords:
obesity; use of herbs; herbal formulation; weight loss; phenylpropanolamine; weight loss;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Preuss, HG Georgetown Univ, Med Ctr, Dept Med, Div Renal, Med Dent Bldg,Room 103 SE,3900 Reservoir Rd NW, Washington, DC 20007 USA Georgetown Univ Med Dent Bldg,Room 103 SE,3900 Reservoir Rd NW Washington DC USA 20007
Citazione:
N.A. Talpur et al., "Influence of a combination of herbs on appetite suppression and weight loss in rats", DIABET OB M, 3(3), 2001, pp. 181-185

Abstract

Aim: We evaluated the ability of a Chinese herbal formulation previously associated with weight loss to influence appetite and weight loss in a carefully controlled laboratory study performed on rats. As a secondary gain. results with this herbal formulation were compared with those from a commonlyavailable phenylpropanolamine (PPA) compound. Design: Eight rats were placed in each arm of a three-arm study, a total of 24 rats. All rats were gavaged with a 2-ml fluid volume containing no addition (control) or the two test substances (combined herbs or PPA) for the first 4 days of the week over 6 consecutive weeks; no gavages were given over weekends. Rats in the two-test groups were given a relatively low dose of the test substance for 3 weeks, followed by a higher dose over the next 3-week periods. Food and water intake were measured for 24-h periods over the ensuing week days. The average daily values for food and water intake foran individual rat were calculated on the basis of collected data over each3-week period. The mean values for each rat obtained over the low- and high-dose periods comprised results from averaging at least 10 measurements. Results: Average daily food intake was decreased only with the herbal formulation, not the PPA compound at the low and high doses. Both the PPA compound and the herbal formulation lowered water intake significantly at the low and high doses. Rats ingesting the herbal formulation at the lower dose had statistically significant lower daily body weight changes over the 3 weeks than those ingesting the PPA compound. At the higher dose, body weight changes for both agents were significantly less than the control, but not significantly different from each other. No evidence of toxicity was seen in the blood chemistries or after histopathological examination. Conclusions: Data collected on rats suggest that the herbal formulation examined might be a useful and safe combination to overcome the overweight state and obesity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:17:36