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Titolo:
Nitric oxide in primary headaches
Autore:
Thomsen, LL; Olesen, J;
Indirizzi:
Lundbeck Inst, Dept Neurol, DK-2942 Skodsborg, Denmark Lundbeck Inst Skodsborg Denmark DK-2942 urol, DK-2942 Skodsborg, Denmark Glostrup Univ Hosp, Dept Neurol, Copenhagen Headache Ctr, Glostrup, Denmark Glostrup Univ Hosp Glostrup Denmark gen Headache Ctr, Glostrup, Denmark
Titolo Testata:
CURRENT OPINION IN NEUROLOGY
fascicolo: 3, volume: 14, anno: 2001,
pagine: 315 - 321
SICI:
1350-7540(200106)14:3<315:NOIPH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICAL SPREADING DEPRESSION; NITROXIDERGIC NERVE FUNCTION; MONKEY CEREBRAL-ARTERIES; TENSION-TYPE HEADACHE; CLUSTER HEADACHE; TRANSCRANIAL DOPPLER; GLYCERYL TRINITRATE; RELAXING FACTOR; SMOOTH-MUSCLE; ANTIMIGRAINE AGENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Thomsen, LL Lundbeck Inst, Dept Neurol, Skodsborg Strandvej 113, DK-2942 Skodsborg, Denmark Lundbeck Inst Skodsborg Strandvej 113 Skodsborg Denmark DK-2942
Citazione:
L.L. Thomsen e J. Olesen, "Nitric oxide in primary headaches", CURR OP NEU, 14(3), 2001, pp. 315-321

Abstract

The molecular mechanisms that underlie the primary headaches-migraine, cluster headache and tension-type headache-have not yet been clarified. On thebasis of studies in headache induced by intravenous infusions of glyceryl trinitrate (an exogenous nitric oxide donor) and histamine (which liberatesnitric oxide from vascular endothelium), it has been suggested that nitricoxide is a likely candidate responsible molecule. The present review dealswith the biology of this small messenger molecule, and the updated scientific evidence that suggests a key role for this molecule in primary headaches. This evidence suggests that the release of nitric oxide from blood vessels, perivascular nerve endings or from brain tissue is an important molecular trigger mechanism in spontaneous headache pain. Pilot trials have shown efficacy of a nitric oxide synthase inhibitor in both migraine attacks and chronic tension-type headache. These observations suggest new approaches tothe pharmacological treatment of headache. Curr Opin Neurol 14:315-321. (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 04/12/20 alle ore 09:47:56