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Titolo:
Immunological update on multiple sclerosis
Autore:
Hohlfeld, R; Wekerle, H;
Indirizzi:
Max Planck Inst Neurobiol, Dept Neuroimmunol, D-82152 Martinsried, GermanyMax Planck Inst Neurobiol Martinsried Germany D-82152 rtinsried, Germany Univ Munich, Klinikum Grosshadern, Inst Clin Neuroimmunol, D-8000 Munich, Germany Univ Munich Munich Germany D-8000 n Neuroimmunol, D-8000 Munich, Germany
Titolo Testata:
CURRENT OPINION IN NEUROLOGY
fascicolo: 3, volume: 14, anno: 2001,
pagine: 299 - 304
SICI:
1350-7540(200106)14:3<299:IUOMS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL VACCINATION; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; ALTERED PEPTIDE LIGAND; CENTRAL-NERVOUS-SYSTEM; BASIC-PROTEIN; BRAIN-LESIONS; B-CELL; CEREBROSPINAL-FLUID; NEUROTROPHIC FACTOR; CLONAL EXPANSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Hohlfeld, R Max Planck Inst Neurobiol, Dept Neuroimmunol, D-82152 Martinsried, Germany Max Planck Inst Neurobiol Martinsried Germany D-82152 ermany
Citazione:
R. Hohlfeld e H. Wekerle, "Immunological update on multiple sclerosis", CURR OP NEU, 14(3), 2001, pp. 299-304

Abstract

The present review of the recent literature focuses on antigen-specific immune reactions in multiple sclerosis. New techniques have allowed precise quantitative analysis of the antigen-receptor repertoire of infiltrating T cells in the multiple sclerosis brain. Novel candidate autoantigens, including B-cell autoantigens, have been identified, 'Humanized' animal models allow the functional characterization of human immune molecules in vivo. Finally, several therapeutic trials have recently assessed the clinical benefit of selective immunotherapies. Curr Opin Neurol 14:299-304. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:40:27