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Titolo:
Magnetic resonance imaging of multiple sclerosis: new insights linking pathology to clinical evolution
Autore:
Matthews, PM; Arnold, DL;
Indirizzi:
McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 surg, Montreal, PQ H3A 2B4, Canada Univ Oxford, Dept Clin Neurol, Oxford, England Univ Oxford Oxford England iv Oxford, Dept Clin Neurol, Oxford, England Univ Oxford, Ctr Funct Magnet Resonance Imaging, Oxford, England Univ Oxford Oxford England ct Magnet Resonance Imaging, Oxford, England
Titolo Testata:
CURRENT OPINION IN NEUROLOGY
fascicolo: 3, volume: 14, anno: 2001,
pagine: 279 - 287
SICI:
1350-7540(200106)14:3<279:MRIOMS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
APPEARING WHITE-MATTER; ADAPTIVE FUNCTIONAL-CHANGES; PERIPHERAL NERVOUS TISSUES; SPINAL-CORD ATROPHY; N-ACETYL-ASPARTATE; STATUS SCALE EDSS; T2 LESION VOLUME; AXONAL INJURY; BRAIN-LESIONS; RAT-BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Arnold, DL McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, 3801 Univ St, Montreal, PQ H3A 2B4, Canada McGill Univ 3801 Univ St Montreal PQ Canada H3A 2B4 2B4, Canada
Citazione:
P.M. Matthews e D.L. Arnold, "Magnetic resonance imaging of multiple sclerosis: new insights linking pathology to clinical evolution", CURR OP NEU, 14(3), 2001, pp. 279-287

Abstract

Magnetic resonance imaging methods allow observation of pathological changes in vivo. Magnetic resonance-based studies have provided a number of important insights into the spatio-temporal evolution of the pathology of multiple sclerosis in vivo, particularly with respect to the relation between pathology and progression of disability. Magnetic resonance techniques have shown that this pathology is not restricted to the plaques that are evident at autopsy, but also involve the so-called normal-appearing white matter. Nonconventional magnetic resonance imaging strategies such as magnetization transfer imaging and spectroscopic imaging provide measures with higher pathological specificity for myelin and axonal injury. These and other advanced magnetic resonance techniques (such as the measurement of atrophy, lesionrelaxation spectra, and lesion dynamics) are affording opportunities to use observations of patients to test biologically specific hypotheses. This should help us to better define new targets for drug therapy and to assess responses to new therapeutic agents. Curr Opin Neurol 14:279-287. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 09:51:54