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Titolo:
Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences
Autore:
Bjartmar, C; Trapp, BD;
Indirizzi:
Cleveland Clin Fdn, Lerner Res Inst, Dept Neurosci NC30, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 i NC30, Cleveland, OH 44195 USA
Titolo Testata:
CURRENT OPINION IN NEUROLOGY
fascicolo: 3, volume: 14, anno: 2001,
pagine: 271 - 278
SICI:
1350-7540(200106)14:3<271:AANDIM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; N-ACETYL-ASPARTATE; APPEARING WHITE-MATTER; DISEASE PROGRESSION; NEUROLOGICAL DISABILITY; COGNITIVE DYSFUNCTION; CORTICAL-LESIONS; MOTOR IMPAIRMENT; BRAIN ATROPHY; IN-VIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Trapp, BD Cleveland Clin Fdn, Lerner Res Inst, Dept Neurosci NC30, 9500 Euclid Ave, Cleveland, OH 44195 USA Cleveland Clin Fdn 9500 Euclid Ave Cleveland OH USA 44195 95 USA
Citazione:
C. Bjartmar e B.D. Trapp, "Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences", CURR OP NEU, 14(3), 2001, pp. 271-278

Abstract

Renewed interest in axonal injury in multiple sclerosis has significantly shifted the focus of research into this disease toward neurodegeneration. During the past year magnetic resonance and morphologic studies have continued to confirm and extend the concept that axonal transection begins at disease onset, and that cumulative axonal loss provides the pathologic substrate for the progressive disability that most long-term MS patients experience, Although inflammation and chronic demyelination are probable causes of axonal transection, little is known about the molecular mechanisms that are involved, The view that MS can also be considered an inflammatory neurodegenerative disease has important clinical implications for therapeutic approaches, monitoring of patients, and future treatment strategies. Curr Opin Neurol 14:271-278 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 05:31:07