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Titolo:
The role of gamma interferon in antimicrobial immunity
Autore:
Shtrichman, R; Samuel, CE;
Indirizzi:
Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA Univ Calif Santa Barbara Santa Barbara CA USA 93106 Barbara, CA 93106 USA Univ Calif Santa Barbara, Interdisciplinary Program Biomol Sci & Engn, Santa Barbara, CA 93106 USA Univ Calif Santa Barbara Santa Barbara CA USA 93106 Barbara, CA 93106 USA
Titolo Testata:
CURRENT OPINION IN MICROBIOLOGY
fascicolo: 3, volume: 4, anno: 2001,
pagine: 251 - 259
SICI:
1369-5274(200106)4:3<251:TROGII>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; SALMONELLA-TYPHIMURIUM INFECTION; SEQUENCE BINDING-PROTEIN; II TRANSACTIVATOR CIITA; IFN-GAMMA; GENE-EXPRESSION; OLIGONUCLEOTIDE ARRAYS; TARGETED DISRUPTION; EPITHELIAL-CELLS; DEFICIENT MICE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
83
Recensione:
Indirizzi per estratti:
Indirizzo: Samuel, CE Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA Univ Calif Santa Barbara Santa Barbara CA USA 93106 93106 USA
Citazione:
R. Shtrichman e C.E. Samuel, "The role of gamma interferon in antimicrobial immunity", CURR OPIN M, 4(3), 2001, pp. 251-259

Abstract

Gamma interferon (IFN-gamma) is an important cytokine in the host defense against infection by viral and microbial pathogens. IFN-gamma induces a variety of physiologically significant responses that contribute to immunity. Treatment of animal cells with IFN-gamma or infection with viral or microbial pathogens leads to changes in the level of expression of several target genes as revealed by DNA microarray analyses. The signaling pathways leading to the induction of IRN-gamma -regulated gene products and, in some cases, their biochemical functions have been defined in exquisite detail. Studies of transgenic mutant mice deficient in proteins of the IFN-gamma responsepathway firmly establish the importance of IFN-gamma in immunity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 11:17:58