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Titolo:
Leptin and its role in lipid metabolism
Autore:
Hynes, GR; Jones, PJH;
Indirizzi:
McGill Univ, Sch Dietet & Human Nutr, St Anne De Bellevue, PQ H9X 3V9, Canada McGill Univ St Anne De Bellevue PQ Canada H9X 3V9 vue, PQ H9X 3V9, Canada
Titolo Testata:
CURRENT OPINION IN LIPIDOLOGY
fascicolo: 3, volume: 12, anno: 2001,
pagine: 321 - 327
SICI:
0957-9672(200106)12:3<321:LAIRIL>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; WHITE ADIPOSE-TISSUE; OBESE GENE-PRODUCT; PLASMA LEPTIN; UNCOUPLING PROTEIN-2; BODY-WEIGHT; FATTY-ACID; ENERGY-EXPENDITURE; RECOMBINANT LEPTIN; MICE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Jones, PJH McGill Univ, Sch Dietet & Human Nutr, MacDonald Campus,21 111 Lakeshore Rd, St Anne De Bellevue, PQ H9X 3V9, Canada McGill Univ MacDonald Campus,21 111 Lakeshore Rd St Anne De Bellevue PQ Canada H9X 3V9
Citazione:
G.R. Hynes e P.J.H. Jones, "Leptin and its role in lipid metabolism", CURR OP LIP, 12(3), 2001, pp. 321-327

Abstract

Since the discovery of leptin in 1994, a considerable amount of research has focused on leptin as a central regulator of body weight. In the animal model, research has demonstrated leptin action through hypothalamic centres altering both satiety and energy expenditure. In contrast to animal studies, it is unlikely that leptin functioning in the human system exerts such a profound role in body weight regulation. Human studies suggest that leptin levels are strongly correlated with both percentage fat mass and body mass index, in accordance with the proposed 'lipostatic theory'. Current research suggests the existence of a unique inter-relationship between dietary fat, leptin expression and leptin action within the peripheral system. More specifically, it has been demonstrated that polyunsaturated fatty acid (PUFA)intake influences adipose tissue expression of leptin, and of several lipogenic enzymes and transcription factors. In addition, leptin stimulates triglyceride depletion in white adipose tissue without increasing free fatty acid release, thus favouring fatty acids versus glucose as a fuel source. Recent studies suggest that the reduction in adipose hypertrophy observed with n-3 PUFA-containing fish oil feeding might involve a leptin-specific process. A large amount of evidence supports direct functioning of leptin in peripheral lipid metabolism in vivo and in vitro. It is possible that PUFAs will maintain an efficient level of circulating leptin, thus preventing leptin insensitivity and weight gain. There has been much recent progress in clinical leptin research, from energy expenditure to leptin analogue efficacy; the purpose of the present review is to summarize our current understanding of leptin functioning. Curr Opin Lipidol 12:321-327. (C) 2001 LippincottWilliams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:39:46