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Titolo:
Roles of acyl-coenzyme A : cholesterol acyltransferase-1 and-2
Autore:
Chang, TY; Chang, CCY; Lin, S; Yu, CJ; Li, BL; Miyazaki, A;
Indirizzi:
Dartmouth Coll, Sch Med, Dept Biochem, Hanover, NH 03755 USA Dartmouth Coll Hanover NH USA 03755 , Dept Biochem, Hanover, NH 03755 USA Shanghai Inst Biochem & Cell Biol, Shanghai, Peoples R China Shanghai InstBiochem & Cell Biol Shanghai Peoples R China ples R China Kumamoto Univ, Sch Med, Dept Biochem, Kumamoto 860, Japan Kumamoto Univ Kumamoto Japan 860 Med, Dept Biochem, Kumamoto 860, Japan
Titolo Testata:
CURRENT OPINION IN LIPIDOLOGY
fascicolo: 3, volume: 12, anno: 2001,
pagine: 289 - 296
SICI:
0957-9672(200106)12:3<289:ROAA:C>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; ATHEROSCLEROTIC LESIONS; ESTERIFICATION ENZYMES; MOLECULAR-CLONING; O-ACYLTRANSFERASE; HUMAN MONOCYTES; ACAT-1 PROTEIN; HUMAN LIVER; FOAM CELLS; COA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Chang, TY Dartmouth Coll, Sch Med, Dept Biochem, Hanover, NH 03755 USA Dartmouth Coll Hanover NH USA 03755 chem, Hanover, NH 03755 USA
Citazione:
T.Y. Chang et al., "Roles of acyl-coenzyme A : cholesterol acyltransferase-1 and-2", CURR OP LIP, 12(3), 2001, pp. 289-296

Abstract

Acyl-coenzyme A:cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and ACAT2) have been identified. Together, these two enzymes are involved in storing cholesteryl esters as lipid droplets, in macrophage foam-cell formation. in absorbing dietary cholesterol, and in supplying cholesteryl esters as part of the core lipid for lipoprotein synthesis and assembly. The key difference in tissue distribution of ACAT1 and ACAT2 between humans, mice and monkeys is that, in adult human liver (including hepatocytes and bile duct cells), the major enzyme is ACAT1, rather than ACAT2. There is compelling evidence implicating a role for ACAT1 in macrophage foam-cell formation, and for ACAT2 in intestinal cholesterol absorption. However, further studies at the biochemical and cell biological levels are needed in order to clarify the functional roles of ACAT1 and ACAT2 in the VLDL or chylomicron synthesis/assembly process. Curr Opin Lipidol 12:280-296 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:31:49