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Titolo:
Living up to a name: the role of the VLDL receptor in lipid metabolism
Autore:
Tacken, PJ; Hofker, MH; Havekes, LM; van Dijk, KW;
Indirizzi:
Leiden Univ, Med Ctr, Dept Human & Clin Genet, NL-2300 RA Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RA NL-2300 RA Leiden, Netherlands Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands Leiden Univ Leiden Netherlands d Ctr, Dept Cardiol, Leiden, Netherlands Leiden Univ, Med Ctr, Dept Internal Med, Leiden, Netherlands Leiden Univ Leiden Netherlands , Dept Internal Med, Leiden, Netherlands Leiden Univ, TNO Prevent & Hlth, Gaubius Lab, Leiden, Netherlands Leiden Univ Leiden Netherlands & Hlth, Gaubius Lab, Leiden, Netherlands
Titolo Testata:
CURRENT OPINION IN LIPIDOLOGY
fascicolo: 3, volume: 12, anno: 2001,
pagine: 275 - 279
SICI:
0957-9672(200106)12:3<275:LUTANT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN-RECEPTOR; TRIGLYCERIDE-RICH LIPOPROTEINS; TISSUE-SPECIFIC EXPRESSION; APOLIPOPROTEIN-E RECEPTOR; MEDIATED GENE-TRANSFER; IN-SITU HYBRIDIZATION; TRANSGENIC MICE; MESSENGER-RNA; UROKINASE RECEPTOR; KNOCKOUT MICE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: van Dijk, KW Leiden Univ, Med Ctr, Dept Human & Clin Genet, POB 9503, NL-2300 RA Leiden, Netherlands Leiden Univ POB 9503 Leiden Netherlands NL-2300RA therlands
Citazione:
P.J. Tacken et al., "Living up to a name: the role of the VLDL receptor in lipid metabolism", CURR OP LIP, 12(3), 2001, pp. 275-279

Abstract

The VLDL receptor (VLDLR) is a member of the LDL receptor family. The VLDLR was hypothesized to mediate fatty acid entry into peripheral tissues, on the basis of its expression in tissues that are active in fatty acid metabolism and its capacity to bind apolipoprotein-E-rich VLDL in vitro. This hypothesis initially proved difficult to confirm, because VLDLR-knockout mice were reported to display normal plasma lipid levels. Moreover, studies in VLDLR-knockout mice that were also deficient in a second LDL receptor familymember, the apolipoprotein E receptor 2, indicated a role for the VLDLR inneuronal migration during brain development. However, in accordance with what the term VLDLR suggests, recent studies using VLDLR-deficient and transgenic mice have provided compelling evidence that the VLDLR does indeed play a role in VLDL-triglyceride metabolism, and that it is important for triglyceride Storage in the adipocyte. Curr Opin Lipidol 12:275-279. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 13:04:10