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Titolo:
Lead compounds discovered from libraries
Autore:
Golebiowski, A; Klopfenstein, SR; Portlock, DE;
Indirizzi:
Procter & Gamble Pharmaceut, Hlth Care Res Ctr, Mason, OH 45040 USA Procter & Gamble Pharmaceut Mason OH USA 45040 s Ctr, Mason, OH 45040 USA
Titolo Testata:
CURRENT OPINION IN CHEMICAL BIOLOGY
fascicolo: 3, volume: 5, anno: 2001,
pagine: 273 - 284
SICI:
1367-5931(200106)5:3<273:LCDFL>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLID-PHASE SYNTHESIS; VANCOMYCIN-RESISTANT BACTERIA; MEDIATED MULTIDRUG-RESISTANCE; COMBINATORIAL CHEMISTRY; PRIVILEGED STRUCTURES; HIGH-AFFINITY; 2,4,5-TRISUBSTITUTED IMIDAZOLES; 4-SUBSTITUTED IMIDAZOLE; SOMATOSTATIN RECEPTOR; NONTOXIC MODULATORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Golebiowski, A Procter & Gamble Pharmaceut, Hlth Care Res Ctr, Mason, OH 45040 USA Procter & Gamble Pharmaceut Mason OH USA 45040 H 45040 USA
Citazione:
A. Golebiowski et al., "Lead compounds discovered from libraries", CURR OP C B, 5(3), 2001, pp. 273-284

Abstract

Lead compounds with the potential to progress to viable drug candidates have been identified from libraries using several strategies. These include rapid screening of large diverse collections, thematic libraries, project-directed libraries, and three-dimensional molecular models of corporate databases. There have been numerous success stories, including the identification of several clinical candidates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:02:11