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Titolo:
Mammalian postmitotic nuclei reenter the cell cycle after serum stimulation in newt/mouse hybrid myotubes
Autore:
Velloso, CP; Simon, A; Brockes, JP;
Indirizzi:
Univ Coll London, Dept Biochem & Mol Biol, London WC1E 6BT, England Univ Coll London London England WC1E 6BT Biol, London WC1E 6BT, England
Titolo Testata:
CURRENT BIOLOGY
fascicolo: 11, volume: 11, anno: 2001,
pagine: 855 - 858
SICI:
0960-9822(20010605)11:11<855:MPNRTC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIMB REGENERATION; MYOGENIC DIFFERENTIATION; MUSCLE DIFFERENTIATION; NEWT MYOTUBES; EXPRESSION; REVERSAL; ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Brockes, JP Univ Coll London, Dept Biochem & Mol Biol, Gower St, London WC1E 6BT, England Univ Coll London Gower St London England WC1E 6BT BT, England
Citazione:
C.P. Velloso et al., "Mammalian postmitotic nuclei reenter the cell cycle after serum stimulation in newt/mouse hybrid myotubes", CURR BIOL, 11(11), 2001, pp. 855-858

Abstract

Cell cycle reentry and dedifferentiation of postmitotic cells are important aspects of the ability of an adult newt and other urodele amphibians to regenerate various tissues and appendages [1], In contrast to their mammalian counterparts, newt Al myotubes are able to reenter S phase after serum stimulation of a pathway leading to phosphorylation of the retinoblastoma protein, pRb [2], The activity in serum is not due to mitogenic growth factorsbut is generated indirectly by the activation of thrombin and subsequent proteolysis [3], In this paper we describe the formation of interspecies hybrid (heterokaryon) myotubes by the fusion of mouse C2C12 [4] and newt Al [5, 6] myogenic cells. The C2C12 nuclei reenter the cell cycle upon serum stimulation of the hybrids, while C2C12 homokaryon myotubes remain arrested under these conditions. These findings indicate that the postmitotic arrest of the mouse nuclei is undermined by the pathway activated in the newt cytoplasm. The hybrid myotubes provide a new model for the manipulation of the postmitotic arrest in both mammalian and newt differentiated cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 07:59:41