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Titolo:
Reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans
Autore:
Pujol, N; Link, EM; Liu, LX; Kurz, CL; Alloing, G; Tan, MW; Ray, KP; Solari, R; Johnson, CD; Ewbank, JJ;
Indirizzi:
Univ Mediterranee, CNRS, INSERM, Ctr Immunol Marseille Luminy, F-13288 Marseille, France Univ Mediterranee Marseille France F-13288 ny, F-13288 Marseille, France Univ Mediterranee, Lab Genet & Physiol Dev, F-13288 Marseille, France UnivMediterranee Marseille France F-13288 ev, F-13288 Marseille, France Glaxo Wellcome Res, Stevenage SG1 2NY, Herts, England Glaxo Wellcome Res Stevenage Herts England SG1 2NY G1 2NY, Herts, England Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Mol Biol, Boston, MA 02114 USA Harvard Univ, Sch Med, Dept Genet, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 ch Med, Dept Genet, Boston, MA 02114 USA NemaPharm Inc, Cambridge, MA 02139 USA NemaPharm Inc Cambridge MA USA 02139 maPharm Inc, Cambridge, MA 02139 USA
Titolo Testata:
CURRENT BIOLOGY
fascicolo: 11, volume: 11, anno: 2001,
pagine: 809 - 821
SICI:
0960-9822(20010605)11:11<809:RGAOCO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
DROSOPHILA HOST-DEFENSE; IMMUNE-RESPONSE; C-ELEGANS; INNATE IMMUNITY; PATHOGEN INTERACTIONS; RECEPTOR FAMILY; PROTEIN; RESISTANCE; INDUCTION; MUTANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Ewbank, JJ Univ Mediterranee, CNRS, INSERM, Ctr Immunol Marseille Luminy, F-13288 Marseille, France Univ Mediterranee Marseille France F-13288 Marseille, France
Citazione:
N. Pujol et al., "Reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans", CURR BIOL, 11(11), 2001, pp. 809-821

Abstract

Background: Both animals and plants respond rapidly to pathogens by inducing the expression of defense-related genes. Whether such an inducible system of innate immunity is present in the model nematode Caenorhabditis elegans is currently an open question. Among conserved signaling pathways important for innate immunity, the Toll pathway is the best characterized. In Drosophila, this pathway also has an essential developmental role. C, elegans possesses structural homologs of components of this pathway, and this observation raises the possibility that a Toll pathway might also function in nematodes to trigger defense mechanisms or to control development. Results: We have generated and characterized deletion mutants for four genes supposed to function in a nematode Toll signaling pathway. These genes are tol-1, trf-1, pik-1, and ikb-1 and are homologous to the Drosophila melanogaster Toll, dTraf pelle, and cactus genes, respectively. Of these four genes, only tol-l is required for nematode development, None of them are important for the resistance of C. elegans to a number of pathogens. On the other hand, C. elegans is capable of distinguishing different bacterial species and has a tendency to avoid certain pathogens, including Serratia marcescens, The tol-1 mutants are defective in their avoidance of pathogenic S. marcescens, although other chemosensory behaviors are wild type. Conclusions: In C, elegans, tol-1 is important for development and pathogen recognition, as is Toll in Drosophila, but remarkably for the latter role, it functions in the context of a behavioral mechanism that keeps worms away from potential danger.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:49:56