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Titolo:
Beneficial effect of glycoprotein IIb/IIIa inhibitor (AZ-1) on endotheliumin Escherichia coli endotoxin-induced shock
Autore:
Pu, Q; Wiel, E; Corseaux, D; Bordet, R; Azrin, MA; Ezekowitz, MD; Lund, N; Jude, B; Vallet, B;
Indirizzi:
Lille Univ Hosp, Dept Pharmacol, Lille, France Lille Univ Hosp Lille France e Univ Hosp, Dept Pharmacol, Lille, France Lille Univ Hosp, Dept Anesthesiol & Intens Care Med, Lille, France Lille Univ Hosp Lille France esthesiol & Intens Care Med, Lille, France Lille Univ Hosp, Dept Hematol, Lille, France Lille Univ Hosp Lille France lle Univ Hosp, Dept Hematol, Lille, France Yale Univ, Sch Med, Div Cardiol, New Haven, CT USA Yale Univ New Haven CTUSA Univ, Sch Med, Div Cardiol, New Haven, CT USA Univ Rochester, Dept Anesthesiol, Rochester, NY USA Univ Rochester Rochester NY USA ter, Dept Anesthesiol, Rochester, NY USA
Titolo Testata:
CRITICAL CARE MEDICINE
fascicolo: 6, volume: 29, anno: 2001,
pagine: 1181 - 1188
SICI:
0090-3493(200106)29:6<1181:BEOGII>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISSEMINATED INTRAVASCULAR COAGULATION; MULTIPLE ORGAN FAILURE; TISSUE FACTOR ACTIVITY; NITRIC-OXIDE SYNTHASE; MONOCLONAL-ANTIBODY; L-ARGININE; PLATELET ACTIVATION; AORTIC ENDOTHELIUM; SEPTIC SHOCK; RAT AORTA;
Keywords:
endotoxin shock; endothelium; platelets; glycoprotein IIb/IIIa; tissue factor; monocyte;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Vallet, B CHU Lille, Dept Anesthesie Reanimat 2, Hop Claude Huriez, F-59037 Lille, France CHU Lille Lille France F-59037 e Huriez, F-59037 Lille, France
Citazione:
Q. Pu et al., "Beneficial effect of glycoprotein IIb/IIIa inhibitor (AZ-1) on endotheliumin Escherichia coli endotoxin-induced shock", CRIT CARE M, 29(6), 2001, pp. 1181-1188

Abstract

Objective: To investigate the effects of AZ-1, a murine monoclonal antiglycoprotein-IIb/IIIa antibody, on endothelium and on hemostasis in a rabbit endotoxic shock model. Design: Prospective laboratory study. Setting: University laboratory. Subjects: Thirty-five male New-Zealand rabbits. Interventions: In vitro vascular reactivity, endothelium CD31-PECAM1 immunohistochemistry, plasma coagulation factors, and monocyte tissue factor determination were performed 1 day and/or 5 days after onset of endotoxic shock (0.5 mg/kg, intravenous bolus, Escherichia coli lipopolysaccharide) with or without treatment by AZ-1 (0.5 mg/kg intravenously) given 1 hr after lipopolysaccharide injection. Measurements and Main Results: Metabolic acidosis and coagulation activation confirmed the presence of shock. AZ-1 treatment improved endothelial-dependent relaxation at 1 day (maximal effect = 87.2 +/- 4.0% vs. 60.9 +/- 5.2% in the nontreated group, p < .05) and at 5 days (maximal effect = 84.5 +/- 3.5% vs. 56.6 +/- 8.2% in the nontreated group, p < .05). Endotoxin-induced endothelial injury was decreased significantly by AZ-1 at 1 day (6.4 +/-1.9% vs. 10.3 +/- 0.8% in the nontreated group, p < .05) and at 5 days (6.3 +/- 2.0% vs. 20.2 +/- 1.2% in the nontreated group, p < .05). Monocyte tissue factor expression was significantly reduced at 5 days. Conclusions: These data indicate that potent inhibition of platelet function via antiglycoprotein-IIb/IIIa receptor blockade can inhibit coagulation activation and protect against endothelial dysfunction and histologic injury in endotoxin-induced shock.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 02:15:32