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Titolo:
Partial liquid ventilation in severely surfactant-depleted, spontaneously breathing rabbits supported by proportional assist ventilation
Autore:
Thome, UH; Schulze, A; Schnabel, R; Franz, AR; Pohlandt, F; Hummler, HD;
Indirizzi:
Univ Ulm, Childrens Hosp, Div Neonatol & Pediat Crit Care, Ulm, Germany Univ Ulm Ulm Germany osp, Div Neonatol & Pediat Crit Care, Ulm, Germany Univ Munich, Dept Obstet & Gynecol, Div Neonatol, Munich, Germany Univ Munich Munich Germany tet & Gynecol, Div Neonatol, Munich, Germany Inst Pathol, Recklinghuasen, Germany Inst Pathol Recklinghuasen GermanyInst Pathol, Recklinghuasen, Germany
Titolo Testata:
CRITICAL CARE MEDICINE
fascicolo: 6, volume: 29, anno: 2001,
pagine: 1175 - 1180
SICI:
0090-3493(200106)29:6<1175:PLVISS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; INTERMITTENT MANDATORY VENTILATION; CONVENTIONAL MECHANICAL VENTILATION; FUNCTIONAL RESIDUAL CAPACITY; HYALINE-MEMBRANE DISEASE; PHRENIC-NERVE ACTIVITY; PULMONARY BLOOD-FLOW; ACUTE LUNG INJURY; GAS-EXCHANGE; EXOGENOUS SURFACTANT;
Keywords:
elastic unloading; resistive unloading; negative ventilator impedance; perfluorocarbon-associated gas exchange; pulmonary lavage; respiratory distress syndrome; compliance; resistance; surfactant deficiency; acute respiratory distress syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Pohlandt, F Univ Ulm, Kinderklin, D-89070 Ulm, Germany Univ Ulm Ulm Germany D-89070 inderklin, D-89070 Ulm, Germany
Citazione:
U.H. Thome et al., "Partial liquid ventilation in severely surfactant-depleted, spontaneously breathing rabbits supported by proportional assist ventilation", CRIT CARE M, 29(6), 2001, pp. 1175-1180

Abstract

Objective: We hypothesized that partial liquid ventilation (PLV) would improve oxygenation in nonparalyzed, surfactant-deficient rabbits breathing spontaneously while supported by proportional assist ventilation (PAV), This ventilation mode compensates for low pulmonary compliance and high resistance and thereby facilitates spontaneous breathing. Design: Randomized trial. Setting: University animal research facility. Subjects: Twenty-six anesthetized New Zealand white rabbits weighing 2592 /- 237g (mean +/- SD). Interventions: After pulmonary lavage (target pan, < 100 mm Hg on mechanical ventilation with 6 cm H2O of positive end-expiratory pressure [PEEP] andan FIO2 of 1.0), rabbits were randomized to PAV (PEEP of 8 cm H2O) with orwithout PLV, PLV rabbits received 25 mL/kg of perfluorocarbon by intratracheal infusion (1 mL/kg/min). Pao(2), Paco(2), tidal volume, respiratory rate, minute ventilation, mean airway pressure, arterial blood pressure, measured. Evaporated perfluorocarbon was refilled every 30 mins in PLV animals. After 5 hrs, animals were killed and lungs were removed. Lung injury was evaluated using a histologic score. Main Results: pan, andcompliance were significantly higher in PLV rabbits compared with controls(P < .05, analysis of variance for repeated measures). All other parameters were similar in both groups. Conclusions: PLV improved oxygenation and pulmonary compliance in spontaneously breathing, severely surfactant-depleted rabbits supported by PAV. Theseverity of lung injury by histology was unaffected.

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Documento generato il 06/04/20 alle ore 01:55:46