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Titolo:
HISTOPATHOLOGY STUDIES IN MELANOMAS OF TH E CHOROID AFTER PROTON-BEAMIRRADIATION
Autore:
BORAN MDS; GRANGE JD; PATRICOT LM; ADELEINE P; CHAUVEL P; CHIQUET C; VITREY D; BEJUI FT;
Indirizzi:
HOP CROIX ROUSSE,LAB ANAT & CYTOL PATHOL F-69317 LYON 04 FRANCE HOP CROIX ROUSSE,SERV OPHTALMOL F-69317 LYON 04 FRANCE HOSPICES CIVILS LYON,DEPT INFORMAT & STAT MED F-69008 LYON FRANCE CTR ANTOINE LACASSAGNE,SERV RADIOTHERAPIE F-06054 NICE FRANCE
Titolo Testata:
Annales de pathologie
fascicolo: 3, volume: 17, anno: 1997,
pagine: 187 - 192
SICI:
0242-6498(1997)17:3<187:HSIMOT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
FRE
Soggetto:
UVEAL MELANOMA; CILIARY BODY; RADIATION; RADIOTHERAPY; ENUCLEATION; THERAPY;
Keywords:
MELANOMAS; CHOROID; UVEAL TUMORS; PROTON BEAM IRRADIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M.D.S. Boran et al., "HISTOPATHOLOGY STUDIES IN MELANOMAS OF TH E CHOROID AFTER PROTON-BEAMIRRADIATION", Annales de pathologie, 17(3), 1997, pp. 187-192

Abstract

To evaluate irradiation effects on choroidal melanomas, histopathologic findings of 18 eyes whose primary treatment was enucleation were compared to 15 eyes enucleated after proton beam irradiation. Irradiatedtumors showed more likely necrosis (p = 0.01) had balloon cells (p = 0.01), and inflammatory infiltrate (p = 0.05). lit the irradiated group, the prevalence of tumor blood vessel damage was higher (p = 0.0002)and mitotic figures were fewer (p = 0.01). These findings suggest that proton beam irradiation damages tumor. cells and alters the tumor's capacity for cellular reproduction. It damages blood vessels leading to tumor necrosis. It induces an inflammatory response of unknown effects. Radiosensitivity of choroidal melanomas cannot be assessed using conventional histologic methods. However, tumor necrosis, mitotic activity and rare of balloon cells can help to establish tumoral sensitivity to irradiation.

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Documento generato il 22/10/20 alle ore 03:09:40