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Titolo:
Platelet glutamate receptor supersensitivity in major depressive disorder
Autore:
Berk, M; Plein, H; Ferreira, D;
Indirizzi:
Univ Witwatersrand, Dept Psychiat, Johannesburg, South Africa Univ Witwatersrand Johannesburg South Africa Johannesburg, South Africa Univ Witwatersrand, Dept Expt & Clin Pharmacol, Johannesburg, South AfricaUniv Witwatersrand Johannesburg South Africa Johannesburg, South Africa
Titolo Testata:
CLINICAL NEUROPHARMACOLOGY
fascicolo: 3, volume: 24, anno: 2001,
pagine: 129 - 132
SICI:
0362-5664(200105/06)24:3<129:PGRSIM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; D-ASPARTATE RECEPTORS; INTRACELLULAR CALCIUM; SCHIZOPHRENIC-PATIENTS; DOUBLE-BLIND; MODEL; ANTIDEPRESSANTS; SEROTONIN; GLYCINE; PLASMA;
Keywords:
depression; psychosis; platelet intracellular calcium response; glutamate; receptor supersensitivity; mood; N-methyl-D-aspartate;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Berk, M Univ Melbourne, Swanston Ctr, Dept Psychiat, POB 281, Geelong, Vic3220, Australia Univ Melbourne POB 281 Geelong Vic Australia 3220 3220, Australia
Citazione:
M. Berk et al., "Platelet glutamate receptor supersensitivity in major depressive disorder", CLIN NEUROP, 24(3), 2001, pp. 129-132

Abstract

Dysregulation of glutamate has been described in depression, and supersensitivity of platelet glutamate receptors has been found in both psychotic major depression and schizophrenia. The aim of this study was to examine the platelet glutamate receptor sensitivity in patients with nonpsychotic, unipolar major depression to assess whether this is a marker of depression or of psychosis. Glutamate receptor sensitivity was assessed using the plateletintracellular calcium response to glutamate (0-100 mu mol) measured by spectrofluorometry. The depression group showed a significantly greater platelet intracellular calcium response to glutamate stimulation than the controlgroup, both in terms of absolute values (p = 0.007) and percentage of response from baseline (p = 0.030). These data suggest that platelet glutamate receptors may be supersensitive in depression and that the platelet may be a possible peripheral marker of glutamate function in depression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/12/19 alle ore 11:09:07