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Titolo:
Dexamethasone affects cytokine-mediated adhesion of HL-60 human promyelocytic leukemia cells to cultured dermal microvascular endothelial cells
Autore:
Patel, NA; Patel, JA; Stins, MF; Kim, KS; Chang, SL;
Indirizzi:
Seton Hall Univ, Dept Biol, S Orange, NJ 07079 USA Seton Hall Univ S Orange NJ USA 07079 , Dept Biol, S Orange, NJ 07079 USA Childrens Hosp, Div Infect Dis, Los Angeles, CA 90027 USA Childrens Hosp Los Angeles CA USA 90027 ct Dis, Los Angeles, CA 90027 USA Univ So Calif, Sch Med, Los Angeles, CA 90027 USA Univ So Calif Los Angeles CA USA 90027 Sch Med, Los Angeles, CA 90027 USA
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 3, volume: 99, anno: 2001,
pagine: 387 - 394
SICI:
1521-6616(200106)99:3<387:DACAOH>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
E-SELECTIN EXPRESSION; NECROSIS-FACTOR-ALPHA; KAPPA-B; MOLECULE EXPRESSION; LEUKOCYTE ADHESION; ICAM-1; INTERLEUKIN-1; VCAM-1; GLUCOCORTICOIDS; MODULATION;
Keywords:
dexamethasone; IL-1 beta; TNF-alpha; LEA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Chang, SL Seton Hall Univ, Dept Biol, 400 S Orange St, S Orange, NJ 07079 USA Seton Hall Univ 400 S Orange St S Orange NJ USA 07079 07079 USA
Citazione:
N.A. Patel et al., "Dexamethasone affects cytokine-mediated adhesion of HL-60 human promyelocytic leukemia cells to cultured dermal microvascular endothelial cells", CLIN IMMUNO, 99(3), 2001, pp. 387-394

Abstract

Leukocyte endothelial adhesion (LEA) is the prelude to a complex cascade of reactions following an immunological challenge. Recently, LEA has been implicated in the molecular basis of several dermatological disorders. While the role of proinflammatory cytokines, such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha), in LEA has been investigated using nondermal models, limited data exist regarding their effects on LEAin dermal models. This study shows that cotreatment of cultured human dermal endothelial cells (CADMEC) with IL-1 beta and TNF-alpha resulted in a marked increase in the adherence of human promyelocytic leukemia (HL-60) cells to CADMEC and an increase in expression of intercellular adhesion molecule-1 and E-selectin, Pretreatment of CADMEC with dexamethasone, a long-lasting glucocorticoid, resulted in a decrease in both HL-60 cell adhesion to CADMEC and adhesion molecule expression. Taken together, these data demonstrate that LEA may play a role in inflammatory skin conditions and in the mechanisms underlying the potential use of glucocorticoids as a treatment option. (C) 2001 Academic Press.

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Documento generato il 05/12/20 alle ore 14:05:38