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Titolo:
NF-kappa B activation in peripheral blood monocytes/macrophages and T cells during acute Kawasaki disease
Autore:
Ichiyama, T; Yoshitomi, T; Nishikawa, M; Fujiwara, M; Matsubara, T; Hayashi, T; Furukawa, S;
Indirizzi:
Yamaguchi Univ, Sch Med, Dept Pediat, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 3, volume: 99, anno: 2001,
pagine: 373 - 377
SICI:
1521-6616(200106)99:3<373:NBAIPB>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; INTERCELLULAR-ADHESION MOLECULE-1; INTRAVENOUS GAMMA-GLOBULIN; TRANSCRIPTION FACTOR; FACTOR-ALPHA; INTERLEUKIN-6; SERUM; MACROPHAGES; EXPRESSION; GENE;
Keywords:
Kawasaki disease; NF-kappa B activation; CD14(+) cells; CD3(+) cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Ichiyama, T Yamaguchi Univ, Sch Med, Dept Pediat, 1-1-1 Minamikogushi, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ 1-1-1 Minamikogushi Ube YamaguchiJapan 7558505
Citazione:
T. Ichiyama et al., "NF-kappa B activation in peripheral blood monocytes/macrophages and T cells during acute Kawasaki disease", CLIN IMMUNO, 99(3), 2001, pp. 373-377

Abstract

Kawasaki disease (KD) is a febrile disease of childhood characterized by systemic vasculitis, and the levels of many proinflammatory cytokines are elevated in the serum at the acute stage. We investigated the activation of transcription factor NF-kappaB for genes that encode the proinflammatory cytokines in CD14(+) monocytes/macrophages and CD3(+) T cells in peripheral blood by means of Western blot and flow cytometric analyses. Western. blot analysis demonstrated that NF-kappaB activation was more increased in CD14(+)monocytes/macrophages than in CD3(+) T cells in all children during the acute stage. Flow cytometric analysis revealed that NF-kappaB activation in CD14(+) monocytes/macrophages was significantly higher than in CD3(+) T cells at the acute stage (30.0 +/- 16.0% vs 11.4 +/- 5.0%, P < 0.01, Wilcoxon test). NF-kappaB activation in CD14(+) mono-cytes/macrophages was significantly decreased after high-dose intravenous immunoglobulin therapy (P < 0.05). The present findings suggest that CD14(+) monocyte/macrophages play an important role in cytokine production during acute KD. (C) 2001 Academic Press.

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Documento generato il 09/04/20 alle ore 07:43:08