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Titolo:
Cytotoxic T cells to an epitope in the islet autoantigen IA-2 are not disease-specific
Autore:
Takahashi, K; Honeyman, MC; Harrison, LC;
Indirizzi:
Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Autoimmun & Transplantat Div, Parkville, Vic 3050, Australia Royal Melbourne Hosp Parkville Vic Australia 3050 le, Vic 3050, Australia
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 3, volume: 99, anno: 2001,
pagine: 360 - 364
SICI:
1521-6616(200106)99:3<360:CTCTAE>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIABETES-MELLITUS; DENDRITIC CELL; HUMAN BLOOD; PREDICTION; PANCREAS; ANTIGENS;
Keywords:
cytotoxic; T lymphocyte; dendritic cell; tyrosine phosphatase IA-2; HLA; type 1 diabetes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Takahashi, K Tohoku Univ, Dept Internal Med 3, Sch Med, Aoba Ku, 1-1 Seiryo Machi, Sendai, Miyagi 98077, Japan Tohoku Univ 1-1 Seiryo Machi Sendai Miyagi Japan 98077 Japan
Citazione:
K. Takahashi et al., "Cytotoxic T cells to an epitope in the islet autoantigen IA-2 are not disease-specific", CLIN IMMUNO, 99(3), 2001, pp. 360-364

Abstract

Cytotoxic CD8 T lymphocytes (CTL) are effecters of pancreatic islet beta -cell destruction in type 1 diabetes but, with the exception of a single report, CTL to islet antigen peptides have not been identified. We used autologous blood monocyte-derived dendritic cells to elicit HLA-A2-restricted CTLto a peptide, MVWES-GCTV (aa 797-805), that is contiguous with a dominant CD4 T-cell epitope in the islet antigen tyrosine phosphatase IA-2, IA-2 peptide-specific CTL activity measured as Cr-51 release from autologous lymphoblasts was detected in 2/6 islet antibody-positive relatives at high risk for type 1 diabetes but also in 2/6 closely HLA-matched controls. All subjects had CTL activity to an HLA-A2-restricted Epstein-Barr virus peptide. CTLto the IA-2 self-peptide were therefore not disease-specific, consistent with other evidence that autoreactive T cells are present in healthy individuals. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:05:59