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Titolo:
Low iron availability modulates the course of Chlamydia pneumoniae infection
Autore:
Al-Younes, HM; Rudel, T; Brinkmann, V; Szczepek, AJ; Meyer, TF;
Indirizzi:
Max Planck Inst Infect Biol, Dept Mol Biol, D-10117 Berlin, Germany Max Planck Inst Infect Biol Berlin Germany D-10117 10117 Berlin, Germany Max Planck Inst Infect Biol, Cent Microbiol Unit, D-10117 Berlin, Germany Max Planck Inst Infect Biol Berlin Germany D-10117 10117 Berlin, Germany
Titolo Testata:
CELLULAR MICROBIOLOGY
fascicolo: 6, volume: 3, anno: 2001,
pagine: 427 - 437
SICI:
1462-5814(200106)3:6<427:LIAMTC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSFERRIN RECEPTORS; EHRLICHIA-CHAFFEENSIS; INTRACELLULAR IRON; ENDOCYTIC PATHWAY; HUMAN-MONOCYTES; CELLS; FUSION; ATHEROSCLEROSIS; ACQUISITION; MACROPHAGES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Meyer, TF Max Planck Inst Infect Biol, Dept Mol Biol, Schumannstr 21-22, D-10117 Berlin, Germany Max Planck Inst Infect Biol Schumannstr 21-22 Berlin Germany D-10117
Citazione:
H.M. Al-Younes et al., "Low iron availability modulates the course of Chlamydia pneumoniae infection", CELL MICROB, 3(6), 2001, pp. 427-437

Abstract

Chlamydiae are obligate intracellular bacteria residing exclusively in host cell vesicles termed inclusions. We have investigated the effects of deferoxamine mesylate (DAM)-induced iron deficiency on the growth of Chlamydia pneumoniae and Chlamydia trachomatis serovar L2. In epithelial cells subjected to iron starvation and infected with either C. pneumoniae or C. trachomatis L2, small inclusions were formed, and the infectivity of chlamydial progeny was impaired. Moreover, for C. trachomatis L2, we observed a delay inhomotypic fusion of inclusions. The inhibitory effects of DAM were reversed by adding exogenous iron-saturated transferrin, which restored the production of infectious chlamydiae. Electron microscopy examination of iron-deprived specimens revealed that the small inclusions contained reduced numbersof C. pneumoniae that were mostly reticulate bodies. We have previously reported specific accumulation of transferrin receptors (TfRs) around C. pneumoniae inclusions within cells grown under normal conditions. Using confocal and electron microscopy, we show here a remarkable increase in the amountof TfRs surrounding the inclusions in iron-starved cultures. It has been shown that iron is an essential factor in the growth and survival of C. trachomatis. Here, we postulate that, for C. pneumoniae also, iron is an indispensable element and that Chlamydia may use iron transport pathways of the host by attracting TfR to the phagosome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:29:18