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Titolo:
Unusual intracellular trafficking of Salmonella typhimurium in human melanoma cells
Autore:
Martinez-Lorenzo, MJ; Meresse, S; de Chastellier, C; Gorvel, JP;
Indirizzi:
Ctr Immunol Marseille Luminy, F-13288 Marseille 9, France Ctr Immunol Marseille Luminy Marseille France 9 3288 Marseille 9, France UFR Med Necker, INSERM, U411, F-75730 Paris, France UFR Med Necker ParisFrance F-75730 INSERM, U411, F-75730 Paris, France
Titolo Testata:
CELLULAR MICROBIOLOGY
fascicolo: 6, volume: 3, anno: 2001,
pagine: 407 - 416
SICI:
1462-5814(200106)3:6<407:UITOST>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYSOSOMAL MEMBRANE-GLYCOPROTEINS; CONTAINING VACUOLES; COMPARTMENTS; MACROPHAGES; BIOGENESIS; APOPTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Gorvel, JP Ctr Immunol Marseille Luminy, Case 906, F-13288 Marseille 9, France Ctr Immunol Marseille Luminy Case 906 Marseille France 9 rance
Citazione:
M.J. Martinez-Lorenzo et al., "Unusual intracellular trafficking of Salmonella typhimurium in human melanoma cells", CELL MICROB, 3(6), 2001, pp. 407-416

Abstract

Salmonella spp. are enterobacteria capable of invading and replicating in both professional and non-professional phagocytes. Here, we investigate thefate of S. typhimurium in human melanoma MelJuSo cells. The bacterium entered MelJuSo cells by a trigger mechanism and resided within a unique organelle, the Salmonella-containing vacuole (SCV). The SCV acquired early endosomal markers transiently and then underwent a series of membrane modifications. In HeLa cells, vacuole maturation is characterized by the simultaneous acquisition of the lysosomal membrane glycoproteins (Lgps) Lamp1, CD63 and vacuolar (v)-ATPase; in MelJuSo cells, however, acquisition of CD63 and v-ATPase preceded that of Lamp1. A very striking event in MelJuSo cells was the arrest of bacterial septation starting from 8 h after infection. Bacterianevertheless continued to elongate, remained morphologically intact and viable and were eventually exocytosed. This original feature was observed in several skin-related cells including melanocytes, suggesting that it may provide the basis for an efficient host defence mechanism against Salmonella infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 05:34:16