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Titolo:
PHARMACOKINETICS AND OVARIAN-STIMULATORY EFFECTS OF EQUINE AND HUMAN CHORIONIC GONADOTROPINS ADMINISTERED SINGLY AND IN COMBINATION IN THE DOMESTIC CAT
Autore:
SWANSON WF; WOLFE BA; BROWN JL; MARTINJIMENEZ T; RIVIERE JE; ROTH TL; WILDT DE;
Indirizzi:
SMITHSONIAN INST,DEPT REPROD PHYSIOL,CONSERVAT & RES CTR,NATL ZOOL PK,1500 REMOUNT RD FRONT ROYAL VA 22630 N CAROLINA STATE UNIV,COLL VET MED RALEIGH NC 27606
Titolo Testata:
Biology of reproduction
fascicolo: 2, volume: 57, anno: 1997,
pagine: 295 - 302
SICI:
0006-3363(1997)57:2<295:PAOEOE>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MARE SERUM GONADOTROPIN; LUTEINIZING-HORMONE; ARTIFICIAL-INSEMINATION; EMBRYONIC MORTALITY; DEVELOPMENTAL COMPETENCE; FOLLICULAR DEVELOPMENT; INVITRO FERTILIZATION; PERIOVULATORY PERIOD; EARLY EMBRYOGENESIS; AROMATASE-ACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
W.F. Swanson et al., "PHARMACOKINETICS AND OVARIAN-STIMULATORY EFFECTS OF EQUINE AND HUMAN CHORIONIC GONADOTROPINS ADMINISTERED SINGLY AND IN COMBINATION IN THE DOMESTIC CAT", Biology of reproduction, 57(2), 1997, pp. 295-302

Abstract

Pregnancy success and embryo survival are low with the use of assisted reproduction in felids treated with exogenous gonadotropins. In thisstudy, the pharmacokinetics and ovarian-stimulatory effects of eCG and hCG were evaluated in the domestic cat. Catheterized anestrual queens (n = 4 per treatment [Trt] group) were given 100 IU eCG i.v. (Trt 1), 100 IU eCG i.m. (Trt 2), 75 IU hCG i.v. (Trt 31, 75 IU hCG i.m. (Trt4), or 100 IU eCG i.m. followed 80 h later by 75 IU hCG i.m. (Trt 5). Blood samples were collected at 0, 5, 30, and 60 min and 4, 8, 12, 24, 36, 48, 72, 96, 120, 144, and 168 h postinjection, and serum sampleswere analyzed for estradiol-17 beta, progesterone, eCG, and hCG. Pharmacokinetic traits (volume of distribution, Vd; elimination half-life,t(1/2 beta); clearance rate, Clr) were calculated for eCG and hCG. When i.v. and i.m. administration were compared, no differences (p > 0.05) were observed in follicle or corpus luteum (CL) number or hormone concentrations for queens receiving eCG or hCG alone. Number of mature ovarian follicles (greater than or equal to 2 mm diameter) observed at168 h postinjection did not differ (p > 0.05) for eCG (mean +/- SEM, 10.5 +/- 2.0) vs. hCG (11.1 +/- 3.0), indicating that these were equally effective in inducing follicular growth. In most queens (> 90%) given single gonadotropins (i.m. or i.v.), eCG and hCG persisted in circulation for at least 120 h and 96 h after injection, respectively, reflecting similar (p > 0.05) pharmacokinetic (i.v.) values for Vd (eCG, 91.4 +/- 24.8 ml/kg; hCG, 59.1 +/- 7.9 ml/kg), t(1/2 beta) (eCG, 23.0 +/- 2.4 h; hCG, 22.9 +/- 4.1 h), and Clr (eCG, 2.7 +/- 0.5 ml/h per kg;hCG, 1.8 +/- 0.1 ml/h per kg). Sequential treatment with eCG + hCG did not affect (p > 0.05) the t(1/2 beta) of individual gonadotropins. In summary, eCG and hCG have comparable pharmacokinetics and ovarian-stimulatory activity when administered alone to the domestic cat. These findings suggest that hCG promotes the ancillary follicle formation that is frequently observed after ovulation in cats treated with eCG + hCG regimens, possibly disrupting the maternal environment and decreasing fecundity following assisted reproductive procedures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 21:51:09